Evidence map›Paper›PMID 41487180›Full record

ArticleACS omega2025

Chalcone Derivatives: Antioxidant Activity, Photoprotective Properties, and Stability under UV Irradiation.

Raphaela P Guaringue, Vinicius M Schaffka, Larissa Kozan, André L Kerek, Eduardo Protachevicz, André V Bassani, Christiana A Pessoa, Patrícia M Campos, Guilherme A Camargo, Barbara C Fiorin

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PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raphaela P GuaringueChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
Vinicius M SchaffkaChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
Larissa KozanChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
André L KerekChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.ORCID https://orcid.org/0000-0002-5449-3619
Eduardo ProtacheviczChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
André V BassaniChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
Christiana A PessoaChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
Patrícia M CamposDepartment of Pharmaceutical Sciences, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.
Guilherme A CamargoDepartment of Pharmacy, Federal University of Paraná, Av. Prefeito Lothário Meissner, 632, Curitiba 80210-170, Brazil.
Barbara C FiorinChemistry Department, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Brazil.ORCID https://orcid.org/0000-0002-2994-7324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of multifunctional photoprotective agents capable of combining ultraviolet (UV) radiation absorption, photostability, and antioxidant activity represents a major challenge in cosmetic science. In this study, a series of 14 chalcone derivatives was synthesized and evaluated for their antioxidant and photoprotective potential. The chalcones, synthesized via the Claisen-Schmidt condensation, were evaluated for their antioxidant activity through DPPH, FRAP, and cyclic voltammetry assays, revealing that compounds 6, 7, and 12 exhibited the highest free radical scavenging capacity, reducing power, and inhibition of lipid peroxidation, with electrochemical data confirming facile oxidation via proton-coupled electron transfer. Photoprotective assessment by the Mansur method demonstrated that these chalcones showed moderate sun protection factor values, with absorption in both UVA and UVB regions and critical wavelengths (λ

Identifiers

PMID41487180
PMCPMC12756833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.