Evidence map›Paper›PMID 41487117›Full record

ArticleFrontiers in systems neuroscience2025

Differential effects of tau expression on seizures and epileptogenesis in a mouse model of temporal lobe epilepsy.

Madeleine C Moseley, Ryan A Cloyd, Liam Burns, Rafael Roberts, Young-Jin Kang, Sang-Hun Lee, Bret N Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in systems neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Seizures drive tau propagation in a tauopathy mouse model.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madeleine C Moseley *Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Ryan A Cloyd *Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, United States.
Liam BurnsDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Rafael RobertsDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY, United States.
Young-Jin KangDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Sang-Hun LeeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Bret N SmithDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Funding

Contribution of adult neurogenesis to epileptogenesis and recovery after TBIR01NS092552 · NINDS · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2018 to 2022
$2.1M
NINDS NIH HHS R01 NS092552
6 · The paper itself

Abstract

Studies of the microtubule-associated protein, tau suggest its promise as a potential target for epilepsy disease modification, but mechanisms underlying tau's effects on seizures are not well-defined. Acquired temporal lobe epilepsy (TLE) is the most prevalent form of focal epilepsy, yet the impact of tau expression on the process of TLE development is unexplored. We investigated tau's role in the epileptogenesis of acquired TLE using the intrahippocampal kainate (IHK) model in mice lacking tau expression (i.e., tau

Indexed as

electroencephalography (EEG)excitatory postsynaptic current (EPSC)inhibitory postsynaptic current (IPSC)intrahippocampal kainatetautemporal lobe epilepsy (TLE)

Identifiers

PMID41487117
PMCPMC12756393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.