Evidence map›Paper›PMID 41487078›Full record

ArticleeLife2026

Identifying new targets in the fight against opioids.

Fernanda Laezza

Abstract readEditorial
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Fernanda LaezzaDepartment of Pharmacology and Toxicology and the Sealy Center for Environmental Health and Medicine, University of Texas Medical Branch, Galveston, United States.ORCID https://orcid.org/0000-0003-1141-1852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.

Indexed as

Analgesics, OpioidFibroblast Growth FactorsAnimalsEpistasis, GeneticMiceAnalgesics, OpioidFibroblast Growth Factorsepistatic interactionsFgf12geneticsgenomicsmouseneuroscienceopioid use disorderOprm1ratregulation of neuronal excitability

Identifiers

PMID41487078
PMCPMC12768405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.