Evidence map›Paper›PMID 41487050›Full record

ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2026

Family quality-of-life burden in chronic spontaneous urticaria: A multicentre study.

Beatrice Martinez Zugaib Abdalla, Roberta Fachini Jardim Criado, Kanokvalai Kulthanan, Emek Kocatürk, Ivan Cherrez-Ojeda, Ana Maria Giménez-Arnau, Marcus Maurer, Luis Felipe Ensina, Jonathan A Bernstein, Michihiro Hide and 24 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Family quality-of-life burden in chronic spontaneous urticaria: A multicentre study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  2. Comment on 'Family quality-of-life burden in chronic spontaneous urticaria: A multicentre study'.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  3. Disease-dependent and independent factors determine the burden of illness among family members.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Beatrice Martinez Zugaib AbdallaCentro Universitário Faculdade de Medicina do ABC, Santo André, Brazil.ORCID https://orcid.org/0000-0003-4586-1915
Roberta Fachini Jardim CriadoCentro Universitário Faculdade de Medicina do ABC, Santo André, Brazil.
Kanokvalai KulthananSiriraj Urticaria and Angioedema Center, Bangkok, Thailand.
Emek KocatürkInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-2801-0959
Ivan Cherrez-OjedaInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1610-239X
Ana Maria Giménez-ArnauHospital del mar & Research Institute, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5434-7753
Marcus MaurerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-4121-481X
Luis Felipe EnsinaFederal University of São Paulo Unifesp, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8652-3619
Jonathan A BernsteinUniversity of Cincinnati College of Medicine, Cincinnati, USA.
Michihiro HideHiroshima University, Hiroshima, Japan.
Sergio Duarte Dortas JuniorClementino Fraga Filho University Hospital, Rio de Janeiro, Brazil.
Solange Oliveira Rodrigues ValleClementino Fraga Filho University Hospital, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-5512-7349
Gabriela DiasPedro Ernesto University Hospital, Rio de Janeiro, Brazil.
Paraskevi XepapadakPanagiotis, and Aglaia Kyriakou Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Priyanshi DangiD Y Patil Hospital, Navi Mumbai, India.
Indrashis PodderCollege of Medicine & Sagore Dutta Hospital, Kolkata, India.ORCID https://orcid.org/0000-0002-9589-083X
Vesna TrajkovaCity General Hospital 'September 8th' - Skopje, Skopje, North Macedonia.
Natasa Teovska MitrevskaRe-Medika Hospital, Skopje, North Macedonia.
Iman Hamed NasrThe Royal Hospital, Muscat, Oman.
Bushra Al HinaiThe Royal Hospital, Muscat, Oman.
Joanna BartosińskaMedical University of Lublin, Lublin, Poland.ORCID https://orcid.org/0000-0003-4106-3051
Dorota KrasowskaMedical University of Lublin, Lublin, Poland.ORCID https://orcid.org/0000-0002-3176-9870
Paulina Szczepanik-KułakMedical University of Lublin, Lublin, Poland.
Hilal GungorHealth Sciences University, Istanbul, Turkey.
Deniz OzcekerHealth Sciences University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-0032-6727
Kübra ÇiçekHacettepe University Medicine Faculty, Ankara, Turkey.ORCID https://orcid.org/0009-0002-7942-588X
Esen Özkayaİstanbul University, İstanbul Faculty of Medicine, Department of Dermatology and Venereology, İstanbul, Turkey.ORCID https://orcid.org/0000-0002-9585-9509
Yasemin Erdemİstanbul University, İstanbul Faculty of Medicine, Department of Dermatology and Venereology, İstanbul, Turkey.ORCID https://orcid.org/0000-0002-6597-2957
Mücahit Ergünİstanbul University, İstanbul Faculty of Medicine, Department of Dermatology and Venereology, İstanbul, Turkey.
Mustafa TosunSivas Cumhuriyet Üniversitesi, Sivas, Turkey.ORCID https://orcid.org/0000-0002-6189-8016
Rabia Oztas KaraSakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0003-1828-5844
Jie LiThe Second Xiangya Hospital of Central South University, Chang Sha Shi, China.ORCID https://orcid.org/0000-0002-0371-1241
Anastasia AllenovaSechenov University, Moscow, Russia.ORCID https://orcid.org/0000-0003-0751-0073
Paulo Ricardo CriadoCentro Universitário Faculdade de Medicina do ABC, Santo André, Brazil.ORCID https://orcid.org/0000-0001-9785-6099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic spontaneous urticaria (CSU) can cause psychosocial and quality of life burden on patients and their family members and caregivers. Despite its recognition as a debilitating disease, limited data exist regarding the impact of CSU on family members, hindering a comprehensive understanding of the disease's broader effects. This study aimed to assess how CSU affects the quality of life of family members who support patients in their daily challenges by applying the Family Dermatology Life Quality Index (FDLQI) questionnaire across multiple countries.

methodsA cross-sectional, multicentre and international study conducted between January and December 2024 in Urticaria Centres of Reference and Excellence (UCARE) centres located in several countries including Brazil, China, Ecuador, Greece, India, Oman, Poland, Russia, Thailand, Turkey, Peru and North Macedonia. Statistical analyses, including non-parametric tests and multiple regression models, were employed to explore associations between disease severity/control and family burden.

resultsPoorly controlled CSU significantly deteriorated family members' quality of life, particularly in emotional, physical and social domains. Higher disease severity and lower disease control scores were associated with increased stress, greater caregiving burden and elevated health expenditures. In opposition to family relations, older age and longer time since diagnosis mitigate negative impacts, while insufficient treatment regimens exacerbated them.

conclusionsInadequate control of CSU amplifies the burden on families, underscoring the need for effective and supportive care strategies.

Indexed as

Chronic UrticariaCost of IllnessFamilyQuality of LifeAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and Questionnaireschronic spontaneous urticariafamily relationshealth expenditureshealth‐related quality of lifehealth status indicatorsomalizumabquality of lifesickness impact profileskin diseaseurticariaantihistamines

Identifiers

PMID41487050
PMCPMC13425259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.