Evidence map›Paper›PMID 41486960›Full record

ArticlePhysiological reports2026

Physiological responses to short-term high-altitude acclimatization: Insights from predictive modeling approaches.

Valeria Páez, Sofia Lozano, Danixza Calfil, David Cristóbal Andrade, Maria Rodriguez-Fernandez

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valeria PáezInstitute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.
Sofia LozanoInstitute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.
Danixza CalfilInstitute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.
David Cristóbal AndradeExercise Applied Physiology Laboratory, Biomedical Department, Faculty of Health Sciences, Universidad de Antofagasta, Antofagasta, Chile.
Maria Rodriguez-FernandezInstitute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-1966-2920

Funding

Agencia Nacional de Investigación y Desarrollo (ANID) 2023-21230255Agencia Nacional de Investigación y Desarrollo (ANID) ACT210083Agencia Nacional de Investigación y Desarrollo (ANID) CIA250016 (CPS-RTC)Agencia Nacional de Investigación y Desarrollo (ANID) NAM24I0095ANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1230844DOD | USAF | AMC | AFOSR | European Office of Aerospace Research and Development (EOARD) AFOSR-SOARD FA9550-24-1-0248
6 · The paper itself

Abstract

High-altitude (HA) exposure induces cardiovascular, respiratory, and metabolic adjustments that often impair exercise performance. These physiological responses depend on hypoxic severity, exposure duration, and individual susceptibility. Although full acclimatization generally requires about 7 days, early adaptations can emerge within the first 72 h. This study aimed to characterize these early responses and to evaluate the potential of mathematical modeling to predict HA-related exercise performance decline. Nine healthy volunteers (age: 24.4 ± 3.3; weight: 63.7 ± 11.8; height: 169.4 ± 8.4; female: 44%) completed maximal cardiopulmonary exercise tests under three conditions: at sea level (SL), and at 3015 m after 12 h (HA12h) and 60 h (HA60h) of exposure. Although 60 h at HA was insufficient for full acclimatization, significant differences were observed between HA12h and HA60h, indicating partial physiological adaptation. Maximal power output declined at both HA time points. Notably, HA-induced performance deterioration was accurately predicted (R

Indexed as

AcclimatizationAltitudeAdultExercise TestFemaleHumansHypoxiaMaleOxygen ConsumptionYoung Adultbaroreflexchemoreflexexercisehigh altitudemachine learningperformance

Identifiers

PMID41486960
PMCPMC12766273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.