Trial reportJournal of cosmetic dermatology2026
A Topical Cosmeceutical Approach to Submental Fullness in Indian Women: 12-Week Prospective Study.
Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Topical Cosmeceutical Approach to Submental Fullness in Indian Women: 12-Week Prospective Study.Journal of cosmetic dermatology · 2026Trial
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubmental fullness ("double chin") is a common aesthetic concern among Indian women. No topical cosmeceutical has been systematically evaluated for this indication.
objectiveTo assess the efficacy of a multi-active topical serum containing DMAE and retinol in reducing submental fullness in Indian women.
methodsThis 12-week, single-center, open-label study enrolled 16 women (ages 18-60) with mild-to-moderate submental fullness; 13 completed the trial. Subjects applied the serum nightly to the submental area. Standardized photographs were obtained at baseline and week 12 and were independently graded by two dermatologists using the validated Clinician-Reported Submental Fat Rating Scale. Any discordance was evaluated and resolved by a third, umpire dermatologist. Body weight was monitored throughout.
resultsAll 13 completers showed visible improvement in submental contour. Dermatologist grading showed statistically significant improvements across all three views (p < 0.05), with the maximum change noted in the left and front profiles (r = 0.88 and 0.83, respectively) compared to the right profile (r = 0.61). Improvements were independent of body weight changes. No adverse events occurred.
conclusionThis preliminary study demonstrates that a DMAE and retinol based topical serum can improve submental fullness in Indian women over 12 weeks, offering a noninvasive alternative to procedural interventions. Larger randomized controlled trials with objective volumetric endpoints are needed for validation.
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