Evidence map›Paper›PMID 41486752›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1-Dependent Signaling Mechanisms.

Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shuyi XuDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ye HeDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ying ZouDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Mengyao ZhaoDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiaqi ZhangDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yizhou XuDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiale CaiDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiongbo LuoDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xinrui MaDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Saini WuDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuling HuangDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xianghai WangDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiasong GuoDepartment of Histology and Embryology, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, National Demonstration Center for Experimental Education, School of Basic Medical Sciences, Department of Neurosurgery, Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-7885-2903

Funding

Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders 2023B1212120004Ministry of Science and Technology China Brain Initiative Grant STI-Major Projects 2022ZD0204700National Natural Science Foundation of China 82071386National Natural Science Foundation of China 82271393National Natural Science Foundation of China 82471417Natural Science Foundation of Guangdong province 2023A1515011726
6 · The paper itself

Abstract

Peripheral nerve myelin is the most cholesterol-rich structure in the body, with the majority of cholesterol being synthesized by Schwann Cells (SCs). Following peripheral nerve injury, myelin disintegration leads to substantial cholesterol release and accumulation, which has been suggested to aggravate neuroinflammation and hinder nerve repair in the central nervous system. However, whether cholesterol synthesis by SCs is detrimental or beneficial for peripheral nerve regeneration remains a critical and unresolved question. Present findings reveal that FDFT1, a key cholesterol biosynthesis enzyme, is downregulated within two weeks post-injury but significantly upregulated thereafter. Conditional knockout (cKO) of Fdft1 in SCs markedly impaired structural and functional recovery in mice after the sciatic nerve crush injury. Mechanistically, SCs' Fdft1 deficiency not only disrupts the cholesterol supply for remyelination but also suppresses the secretion of insulin-like growth factor 1 (IGF1). This impairment of IGF1 signaling further attenuates the axonal regeneration by paracrine mechanisms and disrupts the remyelination via a novel IGF1R/Rap1/PI3K/AKT axis within SCs. In conclusion, this work demonstrates that SC synthesized cholesterol plays dual roles in orchestrating nerve regeneration: it serves as an essential structural component of myelin and also works as a regulator of IGF1 expression to enhance axonal regeneration and remyelination.

Indexed as

CholesterolInsulin-Like Growth Factor INerve RegenerationPeripheral Nerve InjuriesSchwann CellsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutMyelin SheathRemyelinationSciatic NerveSignal TransductionCholesterolInsulin-Like Growth Factor IcholesterolFDFT1IGF1peripheral nerve injurySchwann cell

Identifiers

PMID41486752
PMCPMC13042600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.