Evidence map›Paper›PMID 41486743›Full record

SynthesisThe American journal of sports medicine2026

No Evidence of Superior Graft Remodeling and Maturation When Adding a Lateral Extra-articular Procedure to Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Comparative Studies.

Riccardo D'Ambrosi, Edna Skopljak, Domenico Albano, Carmelo Messina, Salvatore Gitto, Francesca Serpi, Luca Maria Sconfienza

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The American journal of sports medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Pediatric ACL Injuries: A Current Concepts Review.Journal of clinical medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riccardo D'AmbrosiIRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.ORCID 0000-0002-1216-792X
Edna SkopljakDepartment of Orthopedic Surgery, University Medical Centre, Ljubljana, Slovenia.
Domenico AlbanoIRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.
Carmelo MessinaDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Salvatore GittoIRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.
Francesca SerpiIRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.
Luca Maria SconfienzaIRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of postoperative magnetic resonance imaging (MRI) to investigate the effect of concomitant lateral extra-articular procedures (LEAPs) is not well documented in the literature. Few studies have assessed the MRI signal intensity-measured by the signal-to-noise quotient (SNQ)-of the anterior cruciate ligament (ACL) graft between individuals who underwent ACL reconstruction (ACLR) with simultaneous LEAP and those who did not. These comparative studies have produced conflicting results, though, which makes the topic particularly relevant. PURPOSE: To systematically compare existing evidence on graft maturation by performing a meta-analysis of combined ACLR and LEAP versus isolated ACLR. STUDY

designSystematic review and meta-analysis; Level of evidence, 3.

methodsThe methodology adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The PubMed, Embase, and Cochrane Library databases were searched to identify potentially relevant comparative studies that analyzed postoperative graft maturation, at least 10 months after surgery, using MRI with SNQ after isolated ACL or ACL plus LEAP. The Methodological Index for Non-Randomized Studies was used for quality assessment.

resultsA total of 542 patients were included, with 307 receiving isolated ACLR and 235 undergoing combined ACL plus LEAP. Meta-analysis revealed no statistical difference between the groups regarding SNQ (

conclusionAdding a lateral extra articular procedure to ACLR does not improve graft remodeling and maturation. Furthermore, graft maturation is not influenced by the time from surgery, age, or sex. Despite the limited number of studies considered, these findings suggest that a lateral extra-articular procedure does not play a significant role in graft maturation and should be performed selectively.

Indexed as

Anterior Cruciate LigamentAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionHumansMagnetic Resonance ImagingACLanterolateral ligamentgraft maturationmagnetic resonance imagingSNQ

Identifiers

PMID41486743
PMCPMC12916858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.