Evidence map›Paper›PMID 41486690›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

A CD40-OX40 co-stimulatory circuit orchestrates protective CD4

Ximeng Zhang, Jing Yang, Fuxiang Li, Yu Wang, Zhaodong Li, Wenfei Wang, Yunlong Hu, Chenyan Shi, Fan Pan, Carl G Feng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ximeng ZhangGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Jing YangGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Fuxiang LiLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Yu WangGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Zhaodong LiGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Wenfei WangNational Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518000, China.
Yunlong HuGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Chenyan ShiGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Fan PanFaculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518000, China.
Carl G FengSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Yejun WangDepartment of Cell Biology and Genetics, Shenzhen University Medical School, Shenzhen 518000, China.
Qianting YangNational Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518000, China.
Xinchun ChenGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China.
Yi CaiGuangdong Provincial Key Laboratory of Infection Immunity & Inflammation, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen 518000, China. Electronic address: caiyi0113@szu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective CD4

Indexed as

CD40 AntigensCD4-Positive T-LymphocytesMycobacterium tuberculosisReceptors, OX40TuberculosisAnimalsCD40 LigandDisease Models, AnimalHumansLymphocyte ActivationMiceOX40 LigandSignal TransductionCD40 AntigensCD40 LigandOX40 LigandReceptors, OX40CD40Lco-stimulatory signalinghost-directed therapyOX40tuberculosis

Identifiers

PMID41486690
PMCPMC13069330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.