ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- TADs, CGVs, and compartmentalization in genomes: Providing a new way for crop domestication and improvement.Journal of integrative plant biology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
Cotton, a globally vital crop, faces severe yield losses due to heat-induced male sterility. To decipher the thermotolerance mechanisms, we conducted multi-omics analyses (3D chromatin architecture, transcriptome, and epigenome profiling) on heat-tolerant (84021) and heat-sensitive (H05) lines across critical anther developmental stages. We identified subgenome homoeologous gene expression bias linked to thermotolerance, driven by high temperature (HT)-induced dynamic chromatin topology reorganization. The sensitive line exhibited aberrant 3D structural hyperactivation during anther dehiscence, causing deleterious gene overexpression. Central to this regulation is GhAL5, an Alfin-like transcription factor modulated through chromatin loop dynamics and TAD-like boundary reorganization under heat stress. Functional studies confirmed the pivotal role of GhAL5: overexpression enhanced thermotolerance, while RNAi/CRISPR lines showed compromised heat resilience. Remarkably, GhAL5 conferred cross-species heat protection when expressed in rice. Mechanistically, GhAL5 potentially orchestrates male thermotolerance through bidirectional chromatin structure modulation. This study establishes 3D genome plasticity and chromatin remodeling as key drivers of plant thermal adaptation, proposing chromatin-aware breeding strategies for climate-resilient crops.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.