Triplet Energy Transfer-Driven Intermolecular [2+2] Photocycloaddition of Acyclic Imines and Indoles: Facile Access to Azetidine-Fused Indolines.

Gang Yang, Zeng Han, Hong Zhang, Xiuling Cui

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Gang YangKey Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, Engineering Research Centre of Molecular Medicine of Ministry of Education, School of Biomedical Sciences, Huaqiao University, Xiamen, P. R. China.

Zeng HanKey Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, Engineering Research Centre of Molecular Medicine of Ministry of Education, School of Biomedical Sciences, Huaqiao University, Xiamen, P. R. China.

Hong ZhangKey Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, Engineering Research Centre of Molecular Medicine of Ministry of Education, School of Biomedical Sciences, Huaqiao University, Xiamen, P. R. China.

Xiuling CuiKey Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, Engineering Research Centre of Molecular Medicine of Ministry of Education, School of Biomedical Sciences, Huaqiao University, Xiamen, P. R. China.ORCID https://orcid.org/0000-0001-5759-766X

Funding

111 project BC2018061Fujian Province 3502ZCQXT2021006Fujian Provincial Department of Science and TechnologyOpen Research Fund of Academy of Advanced Carbon Conversion Technology, Huaqiao University AACCT0007

6 · The paper itself

Abstract

Currently, successful examples of the aza-[2+2] photocycloaddition (aza-Paternò-Büchi reaction) of indoles primarily rely on intramolecular variants or cyclic imine equivalents. To unlock the full synthetic potential of aza Paternò-Büchi reaction in indoles, it is essential to extend the reaction to acyclic imine. Here, an intermolecular [2+2] photocycloaddition of indoles with acyclic imines has been developed, enabling visible light-mediated aza-Paternò-Büchi reaction by triplet energy transfer. A range of azetidine-fused indolines are successfully provided with yields of up to 93% for 30 examples. Given the growing significance of nitrogen-containing heterocycles in pharmaceutical research and the challenge of their limited accessibility, this study afforded a novel synthetic methodology to construct previously inaccessible structural motifs with high molecular complexity by extending indole intermolecular [2+2] photocycloaddition with acyclic imines.

Indexed as

[2+2] photocycloadditionaza Paternò‐Büchi reactionazetidine‐fused indolines

Identifiers

PMID41486592

DOI10.1002/advs.202516247

PMCPMC12970216

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