Evidence map›Paper›PMID 41486591›Full record

ArticleEpidemiology and psychiatric sciences2026

Onset of exposure to workplace bullying and incident treatment with psychotropic medication - an emulated target trial with 25 309 Swedish and Danish employees.

Rebecka Holmgren, Jeppe Karl Sørensen, Reiner Rugulies, Tianwei Xu, Louise Dalsager, Ida E H Madsen, Linda L Magnusson Hanson

Abstract read
In one paragraph

Article in Epidemiology and psychiatric sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecka HolmgrenStress Research Institute, Division of Psychobiology and Epidemiology, Department of Psychology, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0009-0000-9621-561X
Jeppe Karl SørensenNational Research Centre for the Working Environment, Copenhagen, Denmark.
Reiner RuguliesNational Research Centre for the Working Environment, Copenhagen, Denmark.
Tianwei XuStress Research Institute, Division of Psychobiology and Epidemiology, Department of Psychology, Stockholm University, Stockholm, Sweden.
Louise DalsagerNational Research Centre for the Working Environment, Copenhagen, Denmark.
Ida E H MadsenNational Research Centre for the Working Environment, Copenhagen, Denmark.
Linda L Magnusson HansonStress Research Institute, Division of Psychobiology and Epidemiology, Department of Psychology, Stockholm University, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsExposure to workplace bullying is associated with an increased risk of mental health conditions, yet it is debated whether the association is causal. This study aims to address this by examining whether onset of workplace bullying is associated with initiating treatment with psychotropic medication, here used as a proxy measure for onset of common mental disorders.

methodsWe used two longitudinal datasets from Sweden and Denmark (mean age: 47.4, women: 52.8%), combined with national registry data on psychotropic medication purchases. Using a target trial approach, the study population (

resultsIn total, 1490 individuals (5.9%) experienced onset of workplace bullying. Bullying onset was associated with incident treatment with any psychotropic medication (HR: 1.42, 95% CI 1.15-1.77, model adjusted for sociodemographic variables). This association was attenuated in the fully adjusted model (HR: 1.24, 95% CI 0.99-1.53). In analyses focusing on antidepressant treatment, the estimates were stronger (HR: 1.55, 95% CI: 1.15-2.09, fully adjusted model). The results further demonstrated an exposure-response relationship, such that higher frequency of bullying exposure was associated with an increased risk of initiating any psychotropic treatment and antidepressants.

conclusionsIndividuals experiencing onset of workplace bullying were at higher risk of starting antidepressant treatment within 2 years. This is the first study showing that onset of workplace bullying can contribute to the development of mental health conditions requiring medical treatment. These results underline the importance of preventive interventions that reduce workplace bullying.

Indexed as

BullyingDepressionMental DisordersPsychotropic DrugsWorkplaceAdultDenmarkFemaleHumansLongitudinal StudiesMaleMiddle AgedSwedenPsychotropic Drugsantidepressantscommon mental disordersdepressionoccupational psychiatryprospective studyviolence

Identifiers

PMID41486591
PMCPMC12816931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.