ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
MDP25-VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Host actin remodeling is critical for plant defense against pathogen infection, yet its specific functions remain to be fully explored. This study characterizes the role of the actin cytoskeleton in regulating mitochondrial dynamics to enhance plant defense. We demonstrate that the perception of the bacterial flagellin epitope induces excessive mitochondrial elongation, which facilitates the exchange of mitochondrial components for the functional recovery of damaged mitochondria. This elongation also promotes ATP and mitochondrial ROS production. The formation of elongated mitochondria largely depends on actin bundles in the cortical array. The contribution of actin bundles involves providing structural support for mitochondrial fusion and preventing already elongated mitochondria from undergoing fission. We further identified the interaction between the actin-regulating protein MDP25 and the mitochondrial outer membrane protein VDAC3 in actin remodeling and mediating actin-mitochondria interaction essential for mitochondrial fusion and elongation. Collectively, this study presents a mechanistic model for actin-dependent mitochondrial elongation and its significance for plant immunity.
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