Evidence map›Paper›PMID 41486525›Full record

ArticleJournal of biological rhythms2026

The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function.

Valentina Sica, Tomoki Sato, Ioannis Tsialtas, Sophia Hernandez, Siwei Chen, Pierre Baldi, Pura Muñoz-Cánoves, Paolo Sassone-Corsi, Kevin B Koronowski, Jacob G Smith

Abstract read
In one paragraph

Article in Journal of biological rhythms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Valentina SicaDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Tomoki SatoLaboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.ORCID 0000-0003-3044-6874
Ioannis TsialtasDepartment of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA.ORCID 0000-0001-7164-1743
Sophia HernandezDepartment of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA.
Siwei ChenInstitute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, California, USA.
Pierre BaldiInstitute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, California, USA.ORCID 0000-0001-8752-4664
Pura Muñoz-CánovesDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Paolo Sassone-CorsiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, California, USA.
Kevin B KoronowskiDepartment of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-6808-1789
Jacob G SmithInstitute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.ORCID 0000-0001-5139-1054

Funding

Bioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4M
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
Fundamental Mechanisms of Higher-Order Circadian RhythmsR35GM150618 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kevin B Koronowski · 2023 to 2026
$1.8M
NIAAA NIH HHS R01 AA029124NIGMS NIH HHS R01 GM123558NIGMS NIH HHS R35 GM150618
6 · The paper itself

Abstract

Circadian clocks present throughout the brain and body coordinate diverse physiological processes to support daily homeostasis, yet the specific interorgan signaling axes involved are not well defined. We previously demonstrated that the skeletal muscle clock controls transcript oscillations of genes involved in fatty acid metabolism in the liver, yet the impact of the liver clock on the muscle remained unknown. Here, we use male hepatocyte-specific

Indexed as

Circadian ClocksCircadian RhythmLiverMitochondriaMuscle, SkeletalTranscription, GeneticAnimalsARNTL Transcription FactorsGene Expression RegulationHepatocytesMaleMiceMice, Inbred C57BLMice, KnockoutMuscle Fibers, SkeletalOxidative PhosphorylationARNTL Transcription FactorsBmal1 protein, mouseBmal1circadian clockscircadian rhythmsclock communicationinterorgan crosstalkliver metabolismmitochondriamuscle-liver axisperipheral clocksskeletal muscle

Identifiers

PMID41486525
PMCPMC12774450

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.