Evidence map›Paper›PMID 41486461›Full record

Trial reportJournal of pediatric gastroenterology and nutrition2026

Health-related quality of life in youth with chronic gastrointestinal disease following a biofeedback enhanced cognitive behavioral therapy intervention: A randomized controlled trial.

S Taylor Younginer, Adrianna Westbrook, Jessica Buzenski, Chelly Dykes, Subra Kugathasan, Clair Talmadge, Bonney Reed

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05202418 (Physiological Reactivity and Psychosocial Functioning in Pediatric Patients With Gastrointestinal Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05202418 nacompletednot on this map

Physiological Reactivity and Psychosocial Functioning in Pediatric Patients With Gastrointestinal Disease

TypeinterventionalSponsorEmory UniversityRan2022 to 2024Enrolled53ConditionsInflammatory Bowel Diseases, PsychologicalArmsBiofeedback Enhanced Treatment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S Taylor YounginerEmory University + Children's Healthcare of Atlanta Pediatric Institute, Atlanta, Georgia, USA.
Adrianna WestbrookEmory University School of Medicine, Atlanta, Georgia, USA.
Jessica BuzenskiEmory University + Children's Healthcare of Atlanta Pediatric Institute, Atlanta, Georgia, USA.
Chelly DykesGI Care for Kids, Atlanta, Georgia, USA.
Subra KugathasanEmory University + Children's Healthcare of Atlanta Pediatric Institute, Atlanta, Georgia, USA.
Clair TalmadgeGI Care for Kids, Atlanta, Georgia, USA.
Bonney ReedEmory University + Children's Healthcare of Atlanta Pediatric Institute, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1808-6132

Funding

Brain-Gut biomarkers of anxiety and depressive symptoms in youth with inflammatory bowel diseaseK23DK122115 · NIDDK · EMORY UNIVERSITY · PI REED, BONNEY · 2020 to 2023
$689k
Emory University Pediatric Biostatistics Core RRID: SCR_025834National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health K23DK122115NIDDK NIH HHS K23 DK122115None
6 · The paper itself

Abstract

objectivesPediatric patients with chronic gastrointestinal (GI) conditions including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS) on average endorse lower health related quality of life (HRQOL) than their healthy counterparts. Both diagnoses are conceptualized as products of the brain-gut-axis and impacted by stress responsivity and disease coping. This study examined the effect of a virtual, heart rate variability (HRV) biofeedback enhanced coping skills intervention on HRQOL in pediatric patients with IBD and IBS.

methodsPatients (13-18 years) diagnosed with IBD (N = 51) and IBS (N = 21) were grouped by diagnosis and randomized to immediate treatment or waitlist control groups. The intervention consisted of 6 virtually delivered, weekly group sessions combining cognitive behavioral therapy (CBT) with HRV biofeedback training. Outcomes included youth and parent-rated measures of HRQOL and GI symptoms. Assessments were conducted at baseline and post-intervention.

resultsPostintervention and compared to controls, youth with IBD endorsed improved overall HRQOL as well as improvements in physical, emotional, school, and psychosocial subdomains. No significant changes emerged for youth with IBS postintervention compared to controls. Within the treatment condition, parents of youth with IBD reported improved emotional HRQOL, while parents of youth with IBS reported improved physical and overall HRQOL.

conclusionsThis study offers preliminary support for a biofeedback-enhanced, coping skill intervention for improving patient-reported HRQOL outcomes in youth with IBD. Future studies are needed to understand mechanisms of change for patients with IBD and how the intervention could be tailored to better address HRQOL in patients with IBS.

trial registrationNCT05202418, https://clinicaltrials.gov/study/NCT05202418.

Indexed as

Biofeedback, PsychologyCognitive Behavioral TherapyGastrointestinal DiseasesInflammatory Bowel DiseasesIrritable Bowel SyndromeQuality of LifeAdaptation, PsychologicalAdolescentChronic DiseaseFemaleHumansMaleTreatment Outcomeinflammatory bowel diseaseirritable bowel syndromepediatricstress

Identifiers

PMID41486461
PMCPMC12917793

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.