Evidence map›Paper›PMID 41486457›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Engineered Bacteria-Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity.

Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fei PengDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Zhe LeiDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Zhehao ZhangDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Zhiyue SuDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Chonghai ZhangDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Huan YangDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Shu LiuDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Mengyuan HuDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Yuhong WangDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Lingchuan GuoDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Lin HuDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.ORCID https://orcid.org/0000-0001-8986-3918
Kai YangDepartment of Pathology, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), the First Affiliated Hospital, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.ORCID https://orcid.org/0000-0002-6670-1024

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 32171382Innovative Research Group Project of the National Natural Science Foundation of China 32371461Innovative Research Group Project of the National Natural Science Foundation of China 32471443Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University YXY2301007Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University YXY2304037Jiangsu Provincial Key Research and Development Program BE2022725Key Laboratory of Radiation Damage and Treatment of Jiangsu Provincial Universities and CollegesNatural Science Foundation of the Jiangsu Higher Education Institutions of China 24KJB310017Project Funded by the Priority Academic Program Development of Jiangsu Higher Education InstitutionsSuzhou Fundamental Research Project SJC2023001
6 · The paper itself

Abstract

Radiotherapy (RT) remains a cornerstone in cancer treatment, yet its efficacy is often compromised by tumor-acquired radioresistance, driven in part by lactate accumulation in the tumor microenvironment (TME). Lactate fosters therapeutic resistance through aberrant DNA repair, immunosuppression, and metabolic reprogramming, posing a formidable clinical challenge. Here, we report a precision microbial therapy leveraging engineered Escherichia coli Nissle 1917 (EcNΔnlpI

Indexed as

Colorectal NeoplasmsEscherichia coliLactic AcidRadiation ToleranceAnimalsCell Line, TumorHumansMiceMixed Function OxygenasesTumor Microenvironmentlactate 2-monooxygenaseLactic AcidMixed Function Oxygenasesengineered bacterialactate reprogrammingradioresistancetargeted deliverytumor microenvironment

Identifiers

PMID41486457
PMCPMC13042793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.