Evidence map›Paper›PMID 41486378›Full record

ArticleOral diseases2026

Incident Lung Cancer and Mortality: Data From Health ABC Using Periodontal Status and Tooth Loss.

Taciane Menezes da Silveira, Eleanor M Simonsick, Juliana Balbinot Hilgert, Fernando Neves Hugo, Francisco Wilker Mustafa Gomes Muniz, Natália Marcumini Pola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Taciane Menezes da SilveiraGraduate Dentistry Program, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0002-1863-4146
Eleanor M SimonsickLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, USA.
Juliana Balbinot HilgertDepartment of Preventive and Social Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Fernando Neves HugoDepartment of Epidemiology & Health Promotion, New York University, New York, New York, USA.
Francisco Wilker Mustafa Gomes MunizDepartment of Semiology and Clinic, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0002-3945-1752
Natália Marcumini PolaDepartment of Semiology and Clinic, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0001-9188-7337

Funding

Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996k
DYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793k
HEALTH ABC--COORDINATING UNIT /California/-260062106N01AG062106 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1996 to 2004
$109k
Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorNIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG62101NIA NIH HHS N01AG62103NIA NIH HHS N01AG62106NIA NIH HHS R01 AG028050NIA NIH HHS R01AG028050NIH HHSNINR NIH HHSU.S. Department of Health and Human Services
6 · The paper itself

Abstract

aimTo evaluate whether periodontal parameters and tooth loss are associated with lung cancer incidence and mortality among older adults. MATERIALS AND

methodsData are from the Health, Aging and Body Composition (Health ABC) study, which included 1136 older adults who received a periodontal examination and were followed for up to 16 years. Pocket depth and clinical attachment level were assessed for all present teeth. Adjusted Cox regression models were used to examine the relationship between periodontal parameters and number of natural teeth with lung cancer incidence and mortality.

resultsLung cancer incidence was 4.4% (n = 50) and was identified as cause of death in 3.3% (n = 38). Those presenting at least 10% of sites with probing depth ≥ 6 mm demonstrated a higher risk of lung cancer and death due to lung cancer (hazard ratio [HR]: 3.12, 95% confidence interval [CI]: 1.45-6.72 and HR: 3.08, 95% CI: 1.27-7.46), respectively. Tooth loss was associated with a reduced hazard of lung cancer incidence (HR: 0.96; 95% CI: 0.93-0.99) and related mortality (HR: 0.96; 95% CI: 0.92-0.99).

conclusionThe association between severe periodontal disease parameters and tooth loss with lung cancer among older adults underscores the importance of oral health maintenance for cancer prevention strategies.

Indexed as

Lung NeoplasmsPeriodontal DiseasesTooth LossAgedFemaleHumansIncidenceMaleRisk FactorsUnited Statesaginglung cancerperiodontitistooth loss

Identifiers

PMID41486378
PMCPMC13365001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.