ArticleCurrent microbiology2026
CcTRP1, a Putative TRP Channel in Cordyceps cicadae, Regulates Hyphal Growth, Stress Responses, and Bioactive Metabolite Biosynthesis.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transient receptor potential (TRP) channel family plays crucial roles during diverse physiological processes in plants and animals, yet their functions in fungi remain poorly understood. In this study, we identified five putative TRP homologs in the medicinal fungus Cordyceps cicadae and characterized one, CcTRP1, on its biological roles. Deletion of CcTRP1 impaired mycelial growth but did not affect synnemata morphology. The mutant exhibited altered nitrogen source utilization, showing reduced growth on (NH4)2SO4, NaNO3, and glycine but enhanced growth on tryptone. Additionally, CcTRP1 was involved in stress responses, conferring resistance to osmotic stress (NaCl/KCl) while increasing sensitivity to cell wall stress (Congo red). Transmission electron microscopy revealed a thinner cell wall and abnormal vesicle accumulation in the mutant. Notably, CcTRP1 disruption significantly increased N6-(2-hydroxyethyl)-adenosine (HEA) content while decreasing adenosine level, suggesting its regulatory role in bioactive compound biosynthesis. These findings reveal that CcTRP1 influences hyphal growth, stress adaptation, and secondary metabolism in C. cicadae, providing new insights into the functions of fungal TRP channels.
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