Evidence map›Paper›PMID 41486307›Full record

ArticleLasers in medical science2026

Dual-modality approach with 675 nm laser and microfocused ultrasound for facial aging: retrospective evaluation.

Elena Zappia, Corinna Genovesi, Domenico Piccolo, Federica Trovato, Martina Tolone, Luca Gargano, Alessandro Clementi, Giuseppe Lodi, Annunziata Dattola, Steven Paul Nisticò

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Article in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Elena ZappiaDepartment of Medical Sciences, University of Turin, Turin, Italy. elena.zappia@hotmail.it.
Corinna GenovesiSkin Centers, Private Practice, Avezzano-Pescara, Italy.
Domenico PiccoloSkin Centers, Private Practice, Avezzano-Pescara, Italy.
Federica TrovatoDermatology Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy.
Martina ToloneDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Luca GarganoDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Alessandro ClementiDepartment of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
Giuseppe LodiDermatologic Unit, University of Campania Luigi Vanvitelli, Caserta, Italy.
Annunziata DattolaDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Steven Paul NisticòDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous aging is characterized by gradual structural and functional alterations, including collagen breakdown and reduced elasticity. In recent years, several energy-based modalities have been introduced to address these changes. The aim of this study was to assess the effectiveness of a 675 nm laser and microfocused ultrasound (MFU), applied individually or in combination, for the treatment of facial aging. This retrospective analysis included 115 patients, allocated into three groups: Group A (675 nm laser), Group B (MFU), and Group C (combined protocol). Efficacy was evaluated through the Fitzpatrick Wrinkle Scale (FWS), the Baker Gravitational Ptosis Classification (BGP), and standardized photographic assessments at 1, 3, and 6 months following treatment. At the 6-month evaluation, individuals treated with the combined protocol exhibited a more pronounced improvement in wrinkle reduction (FWS: from 1.88 to 1.13) and laxity reduction (BGP: from 2.78 to 1.55) compared with either single-treatment group. No major side effects were observed. The combined application of the 675 nm laser and MFU appears to potentiate collagen remodeling and skin tightening more effectively than monotherapy. Further prospective studies are needed to validate these results and further clarify the molecular pathways involved.

Indexed as

FaceLow-Level Light TherapySkin AgingUltrasonic TherapyAdultAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment Outcome675 nm laserCollagen stimulationFacial agingHigh frequency ultrasound

Identifiers

PMID41486307
PMCPMC12765735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.