Evidence map›Paper›PMID 41486301›Full record

ReviewNature reviews. Molecular cell biology2026

Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine.

Hao Wu, Hongmei Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hao WuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Hongmei WangState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. wanghm@ioz.ac.cn.ORCID http://orcid.org/0000-0003-1603-4785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human stem cell-based embryo models (hSCBEMs) are emerging as powerful tools in biomedical research owing to their ability to recapitulate the cellular, molecular and structural features of human embryos. These models offer new opportunities to advance our understanding of embryogenesis and to find applications in assisted reproduction, regenerative medicine, precision medicine and drug development. Despite rapid progress, challenges remain in improving the structural, cellular and molecular fidelity, efficiency and standardization of hSCBEMs. This Review discusses recent advances in the development of hSCBEMs and key challenges in their construction and applications, and highlights their translational potential while emphasizing the importance of ethical frameworks and public engagement.

Identifiers

PMID41486301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.