ArticleScientific reports2026
Next-generation polydopamine nanocoatings advancing the understanding of surface properties and antimicrobial efficacy.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Crab Leg-Inspired Poly(Polymer science & technology (Washington, D.C.) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm formation and bacterial colonization on titanium implants pose significant challenges in healthcare, often leading to implant failure. Surface modifications using nanotechnology offer a promising approach to improve antibacterial properties while maintaining biocompatibility. To evaluate the surface characteristics, cytocompatibility, and antibacterial efficacy of titanium discs coated with polydopamine (PDA) alone versus PDA combined with poly (MBAAm-co-SBMA) zwitterionic nanoparticles. This in vitro comparative study involved the coating of titanium discs into two groups: Group 1 (PDA-coated) and Group 2 (PDA + poly (MBAAm-co-SBMA) zwitterionic nanoparticle-coated). poly (MBAAm-co-SBMA) zwitterionic nanoparticles were synthesized using the distillation-precipitation polymerization method. Surface morphology and Surface Roughness was analyzed using field emission scanning electron microscopy (FESEM) and Atomic force Microscopy (AFM), and elemental composition was determined via energy-dispersive spectroscopy (EDS). Cell viability was assessed using BCA protein assay in, while antibacterial activity against Streptococcus mutans was evaluated using the disk diffusion method. Statistical analysis was conducted using one-way ANOVA with a post-hoc Tukey test (p < 0.05), and results were reported as mean ± standard deviation . FESEM revealed uniform nanoparticle deposition with globular morphology PDA + poly (MBAAm-co-SBMA) zwitter ion nanoparticles. EDS confirmed increased carbon presence in the zwitterion-coated group. Cell viability was comparable between PDA (49.1%) and PDA + poly (MBAAm-co-SBMA) zwitterion (52.5%) groups. PDA + poly (MBAAm-co-SBMA) zwitterion group showed a significantly reduced S. mutans colony count (1.25 × 10⁴ CFU/mL) versus Group 1 (1.4 × 10⁵ CFU/mL). Conclusion Even though Polydopamine has significant antibacterial activity as evidenced in literature, it was observed in this study that, PDA-poly (MBAAm-co-SBMA) zwitterionic nanoparticle coatings demonstrated superior antibacterial activity and favourable surface morphology than PDA, without compromising cytocompatibility, making them suitable for reducing biofilm-associated infections on titanium implants.
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