Evidence map›Paper›PMID 41486293›Full record

ArticleCell research2026

Targeting PTPN13 with 11-amino-acid peptides of C-terminal APC prevents immune evasion of colorectal cancer.

Wen-Hui Ma, Wen-Yi Li, Tao Chen, Linqian Jing, Yue-Hong Chen, Kejun Li, Zhuo-Luo Xu, Rong-Fang Shen, Yutong He, Tingyu Mou and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Wen-Hui Ma *State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Wen-Yi Li *State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Tao Chen *State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Linqian Jing *State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, China.
Yue-Hong ChenState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Kejun LiState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhuo-Luo XuState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Rong-Fang ShenState Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yutong HeThe Fifth Affiliated Hospital of Southern Medical University, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Tingyu MouState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ting-Yue LuoState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiangnan SunState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, China.
Zhao-Kun WuState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Li-Jing WangVascular Biology Research Institute, School of Life Sciences and Biopharmaceuticals, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Hong-Juan LiuCancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Xiaozhong QiuThe Fifth Affiliated Hospital of Southern Medical University, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Yi GaoGeneral Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-4536-6191
Xiaochun BaiState Key Laboratory of Multi-organ Injury Prevention and Treatment, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0001-9631-4781
Wei WangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Dalei WuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, China.ORCID 0000-0003-1817-7229
Guoxin LiState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0003-2773-7048
Wei-Jie ZhouState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. weijiezhouum@163.com.ORCID 0000-0002-0021-9454

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82441036
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains largely refractory to immune-checkpoint blockade, with adenomatous polyposis coli (APC) mutations present in 80%-90% of cases. Loss of APC was previously thought to promote tumor progression mainly through deregulated Wnt/β-catenin signaling. Here, we report that APC loss leads to inhibition of CD8

Indexed as

Adenomatous Polyposis Coli ProteinColorectal NeoplasmsImmune EvasionPeptidesTumor EscapeAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansMiceMice, Inbred C57BLPhosphorylationSTAT1 Transcription FactorAdenomatous Polyposis Coli ProteinPeptidesSTAT1 protein, humanSTAT1 Transcription Factor

Identifiers

PMID41486293
PMCPMC12765898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.