ArticleJournal of nanobiotechnology2026
Biomimetic "Tendon Band-Aid" regulates inflammatory microenvironment and tenogenic differentiation for tendinopathy regeneration.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Biglycan Reconstitutes a Neonatal ECM Signaling Microenvironment to Drive Stem Cell-Mediated Tendon Regeneration via a Scaffold-Free Cell Sheet Platform.International journal of molecular sciences · 2026Article
- Exosome-mediated tendon-derived stem cell therapy strategies: potential and challenges.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Tendinopathy (TDP) is a common yet challenging chronic degenerative condition characterized by disrupted inflammatory microenvironments, cellular dysfunction and tissue structural degradation. Drawing inspiration from the protective and drug-releasing functions of adhesive bandages, this study has developed a biomimetic "Tendon Band-Aid" using electrospinning and photocrosslinking techniques to modulate anti-inflammatory and regenerative processes within the tendon microenvironment. Gelatin methacrylate and gelatin vanillin hydrogel fibers (GV) were used as nanofiber patches to cover damaged tendons, enabling the sustained release of ibuprofen (ibu) within the local inflammatory microenvironment. In vitro experiments confirmed that the biomimetic "Tendon Band-Aid" (GV@ibu) effectively alleviates local inflammatory responses by inhibiting the AGEs/NF-κB/COX-2 pathway and guiding tendon stem cells (TSCs) towards tenogenic differentiation. It also promotes the reorganization of the extracellular matrix (ECM). In vivo studies further demonstrate the patch's ability to significantly improve collagen tissue structure and restore motor function in tendinopathy models. Consequently, this multifunctional GV@ibu patch, which combines inflammation resolution and tenogenesis, shows great potential as an ideal solution for the regenerative repair of tendinopathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.