Evidence map›Paper›PMID 41486122›Full record

ArticleBMC neurology2026

Effect of deep brain stimulation on early-onset Parkinson's disease with mutations in a Han Chinese Mainland population.

Si Chen, Ning Yang, Jinde Liu, Shujun Xu, Shuo Xu, Jiwei Wang, Chao Li, Yi-Ming Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Si Chen *Department of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Ning Yang *Department of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Jinde LiuDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Shujun XuDepartment of Neurosurgery, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, P.R. China.
Shuo XuDepartment of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Jiwei WangDepartment of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Chao LiDepartment of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China. lee810115@hotmail.com.
Yi-Ming LiuDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China. liuym@sdu.edu.cn.

Funding

National Natural Science Foundation of China 82171245Natural Science Foundation of Shandong Province ZR2022MH155
6 · The paper itself

Abstract

backgroundThe influence of genetic factors on the efficacy of deep brain stimulation (DBS) remains unclear. This study aimed to analyze the effects of DBS in Han Chinese patients with early-onset Parkinson’s disease (EOPD) across various genetic backgrounds and to explore the differences in DBS responsiveness among patients EOPD with and distinct genetic profiles.

methodsThis retrospective study examined 48 patients with EOPD who underwent DBS. Patients were divided into mutation-positive (Mut+) and mutation-negative (Mut-) groups. Clinical evaluations were performed before and 24 months after DBS using the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale, Non-Motor Symptoms Scale for Parkinson’s Disease, and levodopa-equivalent daily dose (LEDD).

resultsIn the Mut + group, 16 patients with EOPD carried gene mutations: seven in PRKN, four in GBA, three in PLA2G6, one in LRRK2, and one in PINK1. Fifteen patients had no detectable pathogenic mutations (Mut- group). The two groups had similar baseline demographic characteristics and preoperative clinical features, except for a younger age at onset in the Mut + group. Both the groups derived benefits from DBS surgery, with no statistically significant differences observed between them in terms of motor symptoms improvement and LEDD reduction at 24 months post-DBS. Furthermore, DBS responses varied according to genetic subtype, with the PLA2G6 subgroup demonstrating relatively poor outcomes, especially in terms of non-motor symptoms and axial symptoms. Regarding non-motor symptoms, DBS showed no significant differences in non-motor symptom improvement between the two groups or among the various genetic subgroups.

conclusionsDBS is effective in improving motor symptoms and reducing the LEDD in patients with EOPD, regardless of their genetic background. However, patients with genetic mutations, especially in PLA2G6, may show a weaker response to DBS, highlighting the need for personalized approaches in DBS therapy for EOPD.

Indexed as

Deep Brain StimulationMutationParkinson DiseaseAdultAge of OnsetChinaEast Asian PeopleFemaleGlucosylceramidaseGroup VI Phospholipases A2HumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiddle AgedProtein KinasesPTEN-Induced Putative KinaseGBA protein, humanGlucosylceramidaseGroup VI Phospholipases A2Leucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesDeep brain stimulationEarly-onset parkinson’s diseaseGeneticsHan chineseMutations

Identifiers

PMID41486122
PMCPMC12870255

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.