Evidence map›Paper›PMID 41486087›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways.

Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin and 11 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yang LuanSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-2211-7803
Yubo ZhangState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-4232-5407
Jingjing LiState Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.
Jianqing ZhuShanghai Zoological Park, Shanghai, China.
Yuyang LeiSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yushi HuSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenqiang XinShanghai Standard Technology Co., Ltd, Shanghai, China.
Tianpei XieShanghai Standard Technology Co., Ltd, Shanghai, China.
Jiang ZhengWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Yuanyuan LinWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Jingjing ShenShimazu (China) Co., Ltd, Shanghai Branch, China.
Yiyi CaoSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xinyue YouSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing XiSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiaying WuSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiying LiuSchool of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xinyu ZhangSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuanting ZhengState Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.
David J LohmanDepartment of Biology, City College of New York, New York, New York, USA.
Leming ShiState Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.
Wei ZhangState Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking University, Beijing, China.

Funding

National Natural Science Foundation of China 32170420National Natural Science Foundation of China 32325009National Natural Science Foundation of China 41991314
6 · The paper itself

Abstract

Aristolochic acids (AAs) are natural compounds found in Aristolochiaceae plants, to which humans are frequently exposed through environmental and medicinal sources. AAs are highly nephrotoxic and carcinogenic, mediated by oxidative stress and bioactivation-induced DNA damage and mutagenicity. Nevertheless, some Lepidoptera, including Pachliopta aristolochiae, feed exclusively on Aristolochiaceae and sequester AAs as a chemical defense. This is uncommon in nature and it is not yet fully understood how these insects avoid the lethal effects of AAs. To address this question, we investigate Pac. aristolochiae's AA-resistance mechanisms by employing metabolic analyses, multiomics analyses, in situ imaging and more. Our findings indicate that AAs may be detoxified through biotransformation and a robust antioxidant system, involving candidate genes such as 15-oxo-prostaglandin 13-reductases (PGRs), cytochrome P450s, and catalases. Unexpectedly, DNA adducts, the covalent binding products from activated AA intermediates, are detected across most life stages of Pac. aristolochiae, revealing that Pac. aristolochiae can maintain genomic integrity despite a substantial burden (reaching over 1800 AA-DNA adducts per 10

Indexed as

Aristolochic AcidsButterfliesAnimalsAristolochiaBiological EvolutionDNA AdductsDNA DamageOxidative StressAristolochic AcidsDNA AdductsantioxidantAristolochiaceaebutterflieschemical defenseDNA repairmultiomics

Identifiers

PMID41486087
PMCPMC13045329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.