Evidence map›Paper›PMID 41485978›Full record

ArticleThe Journal of veterinary medical science2026

Successful therapy of a dog with trapped neutrophil syndrome using a combination of cyclosporine and prednisolone: a case report.

Ryo Miyamoto, Risa Kiyota, Tetsuro Ito, Hirotaka Igarashi, Sakurako Neo, Shinichiro Kimoto, Yoshiharu Ohsato, Junichi Kamiie, Masaharu Hisasue

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryo MiyamotoLaboratory of Veterinary Small Animal Internal Medicine, Iwate University, Iwate, Japan.
Risa KiyotaAzabu University Veterinary Teaching Hospital, Azabu University, Kanagawa, Japan.
Tetsuro ItoLaboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, Kanagawa, Japan.
Hirotaka IgarashiLaboratory of Small Animal Internal Medicine, Azabu University, Kanagawa, Japan.
Sakurako NeoLaboratory of Clinical Diagnosis, Azabu University, Kanagawa, Japan.
Shinichiro KimotoKimoto Animal Hospital, Tokyo, Japan.
Yoshiharu OhsatoKahotechno Co., Ltd., Fukuoka, Japan.
Junichi KamiieLaboratory of Pathology, Azabu University, Kanagawa, Japan.
Masaharu HisasueLaboratory of Small Animal Internal Medicine, Azabu University, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trapped Neutrophil Syndrome (TNS) is a rare, fatal, autosomal recessive disease in Border Collies. A 7-month-old female Border Collie with TNS presented with fever, diarrhea, occasional vomiting, lameness, and severe neutropenia. The diagnosis was confirmed by bone marrow examination and vacuolar protein sorting-associated protein 13B (VPS13B) gene mutation analysis. Initial treatment with prednisolone improved symptoms; however, relapse occurred during tapering, and the addition of cyclosporine resolved the symptoms, allowing successful tapering of prednisolone. The dog remained symptom-free for 7.4 months and survived for 33 months. Cyclosporine may be associated with increased C-X-C chemokine receptor type 4 mRNA expression, possibly reducing the risk of infection and fever. Based on these findings, a combination of cyclosporine and prednisolone may represent a potential treatment option for TNS.

Indexed as

CyclosporineDog DiseasesImmunosuppressive AgentsNeutropeniaPrednisoloneAnimalsCongenital Bone Marrow Failure SyndromesDogsDrug Therapy, CombinationFemaleVesicular Transport ProteinsCyclosporineImmunosuppressive AgentsPrednisoloneVesicular Transport Proteinscanine (dog)C-X-C chemokine receptor type 4 (CXCR4)cyclosporinetrapped neutrophil syndrome (TNS)

Identifiers

PMID41485978
PMCPMC13000427

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.