Evidence map›Paper›PMID 41485912›Full record

ArticleInternal medicine (Tokyo, Japan)2026

A 15-year Follow-up of Persistent Pulmonary Lesions after Silicone Removal in a Patient with Silicon-induced Autoimmune/Inflammatory Syndrome.

Natsumi Watanabe, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Xintao Wang, Naoko Fukuhara, Tetsuya Egawa, Takahiro Kumanaka, Ryutaro Tanaka and 15 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Natsumi WatanabeDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Yoshinori TaninoDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Takefumi NikaidoDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Yuki SatoDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Ryuichi TogawaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Xintao WangDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Naoko FukuharaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Tetsuya EgawaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Takahiro KumanakaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Ryutaro TanakaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Kentaro KazamaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Koshi SaitoDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Rina HariganeDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Ryuki YamadaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Riko SatoDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Hikaru TomitaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Mami RikimaruDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Takashi UmedaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Yasuhito SuzukiDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Junpei SaitoDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Kenya KanazawaDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.
Hiroyuki SuzukiChest Surgery, Fukushima Medical University, Japan.
Yuko HashimotoDiagnostic Pathology, Fukushima Medical University, Japan.
Akira HebisawaClinical Research Center, National Hospital Organization Tokyo National Hospital, Japan.
Yoko ShibataDepartment of Pulmonary Medicine, Fukushima Medical University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 65-year-old woman with a history of silicone breast implantation was admitted to our hospital with abnormal chest shadows. Although the implants had already been removed, chest CT revealed diffuse ground-glass opacities in both lungs. Thoracoscopic lung biopsy revealed non-necrotizing epithelioid granulomas and silica-phagocytic macrophages, leading to a diagnosis of silicone-implant-associated autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Over a follow-up period of more than 15 years without treatment, the ground-glass opacities improved only slightly. We herein present the longest follow-up chest CT findings of silicone implant-associated ASIA.

Indexed as

Autoimmune DiseasesAutoimmune-Inflammatory Syndrome Induced by AdjuvantsBreast ImplantsLung DiseasesSiliconSiliconesAgedFemaleFollow-Up StudiesHumansLungTomography, X-Ray ComputedSiliconSiliconesautoimmune/inflammatory syndrome induced by adjuvantspersistent pulmonary shadowssilicone implantSjögren's syndrome

Identifiers

PMID41485912
PMCPMC13521642

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