Evidence map›Paper›PMID 41485699›Full record

ArticleChest2026

Do Young Individuals With Chronic E-Cigarette Exposure Display Cardiopulmonary Abnormalities During Exercise and Blunted Recruitment of Pulmonary Diffusing Capacity?

Thomas G Williams, Sophie É Collins, Andrew R Brotto, Andrew W D'Souza, Cameron M Ehnes, Bronwen Hicks, Jason Weatherald, Janice M Leung, Michael K Stickland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas G WilliamsDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Sophie É CollinsResearch Institute of the McGill University Health Centre and McGill University, Montréal, QC, Canada.
Andrew R BrottoDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Andrew W D'SouzaDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Cameron M EhnesDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Bronwen HicksDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Jason WeatheraldDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Janice M LeungDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.
Michael K SticklandDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. Electronic address: michael.stickland@ualberta.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of e-cigarette use is increasing, and young adults who report e-cigarette use and no history of tobacco smoking report greater respiratory symptoms. Traditional evaluation of resting pulmonary function may fail to detect subclinical abnormalities. RESEARCH QUESTION: To what extent do otherwise healthy, young adults who report regular e-cigarette use and no tobacco smoking history exhibit altered cardiopulmonary function during exercise and blunted recruitment of pulmonary diffusing capacity for carbon monoxide (Dlco)? STUDY DESIGN AND

methodsTwenty participants with chronic e-cigarette exposure (mean age, 23 ± 4 years) with no tobacco smoking history and 20 age-, height-, and sex-matched control participants underwent a pulmonary function test and cardiopulmonary exercise test. Key outcomes included exercise capacity (V˙O

resultsBoth groups presented with normal pulmonary function (all, P

interpretationIn this study, otherwise healthy young adults who report regular e-cigarette use exhibited evidence of abnormal cardiopulmonary responses to exercise and blunted Dlco recruitment. These findings suggest early cardiopulmonary impairment and pulmonary vascular dysfunction in young adults with chronic e-cigarette exposure.

Indexed as

Electronic Nicotine Delivery SystemsExerciseLungPulmonary Diffusing CapacityVapingAdultCase-Control StudiesExercise TestExercise ToleranceFemaleHumansMaleRespiratory Function TestsYoung Adultcardiopulmonary exercise testingdiffusing capacitydyspneaelectronic cigarettesventilation

Identifiers

PMID41485699
PMCPMC13269680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.