ArticleBrain stimulation
Effects of low-frequency burst stimulation of the motor thalamus on cortical neural co-firing.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
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6 authors.
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Abstract
backgroundElectrical stimulation targeting the motor thalamus (Mthal) represents an emerging strategy for regulating motor cortical activity patterns, however the fundamental mechanisms and optimal stimulation configurations are not well established.
objectiveTo characterize how burst Mthal stimulation modulates cortical activity and to identify stimulation parameters that maximize cortical co-firing via thalamocortical rebound mechanisms.
methodsWe conducted acute electrophysiological experiments in anesthetized rats using Mthal stimulation with systematically manipulated burst stimulation parameters (i.e., number of pulses and pulse width) in the low-frequency band (1-8 Hz) modulation cycle. Cortical responses across large areas covering primary and secondary motor cortex were recorded. Additionally, intracortical recordings were performed for detailed spike activity monitoring during stimulation. Cortical activity patterns in local field potentials and spike activity were analyzed to quantify the effects of Mthal stimulation on motor cortex. Computational thalamocortical circuit models were employed to explore the mechanistic basis of frequency-selective modulation effects.
resultsBurst Mthal stimulation elicited tunable cortical excitation, with optimal modulation achieved at 3-4 Hz. This preferred frequency corresponded to the natural rebound timing of thalamocortical (TC) cells and generated maximal cortical co-firing and synchronization. Higher stimulation frequencies (e.g., 8 Hz) resulted in suppressed and diminished responses. Computational modeling further validated that the cellular mechanism of the TC cell rebound excitation leads to frequency-dependent cortical modulation.
conclusionBurst Mthal stimulation demonstrates frequency-selective modulation of cortical network excitability, with 3-4 Hz protocols providing optimal enhancement of synchronized activity through exploitation of thalamocortical rebound dynamics. These results establish motor thalamic stimulation as a promising and efficient methodology for precise cortical network control and offer mechanistic foundations for developing therapeutic neuromodulation interventions aimed at motor system rehabilitation.
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