Evidence map›Paper›PMID 41485513›Full record

ArticleJournal of affective disorders2026

Insomnia longitudinally predicts reduced reward motivation in adults with elevated depressive symptoms.

Shirley Wu, D Gage Jordan, Devika Goel, E Samuel Winer, Naoise Mac Giollabhui, Amanda C Collins

Abstract read
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shirley WuDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. Electronic address: swu24@mgh.harvard.edu.
D Gage JordanDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Devika GoelDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
E Samuel WinerDepartment of Psychology, The New School for Social Research, New York, NY, United States.
Naoise Mac GiollabhuiDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
Amanda C CollinsDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.

Funding

Reward Devaluation, Positive Valence Systems Disturbance, and ImpairmentR15MH101573 · NIMH · NEW SCHOOL UNIVERSITY · PI E. Samuel Winer · 2014 to 2026
$1.8M
The role of inflammation in cognitive dysfunction in acute depression as determined by experimental inhibition of tumor necrosis factor-alphasignaling in a randomized controlled trial.K23MH132893 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Naoise Mac Giollabhui · 2024 to 2026
$592k
AMP-C: A Digital Therapeutic for Reward Dysfunction in Co-Occurring Depression and Cannabis UseK23DA062034 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI Amanda Claire Collins · 2025 to 2026
$395k
NIDA NIH HHS K23 DA062034NIMH NIH HHS K23 MH132893NIMH NIH HHS R15 MH101573
6 · The paper itself

Abstract

Sleep disturbance and reward dysfunction are both strongly associated with the onset and persistence of depressive disorders. Given this, examining their longitudinal associations within depression may provide important clinical insights. Existing research has not examined the relationship between sleep disturbance and reward dysfunction in depression over time, nor has it clarified the directionality of this relationship or the potential mediating or moderating role of sleep disturbance between depression and reward motivation. This study addresses these gaps by investigating these relationships among reward motivation, insomnia, and depressive symptoms in an adult population. The study included 101 community dwelling adults (M

Indexed as

DepressionMotivationRewardSleep Initiation and Maintenance DisordersAdultFemaleHumansLongitudinal StudiesMaleYoung AdultAdultsDepressionEEfRTInsomniaReward motivationSleep disturbance

Identifiers

PMID41485513
PMCPMC12990224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.