Evidence map›Paper›PMID 41485508›Full record

ArticleJournal of affective disorders2026

Fatigue in major depression is linked to depression severity, not sleep duration or anterior cingulate cortex neurochemistry.

Samir Batheja, Jie Yang, Yunhan Liao, Kenneth Wengler, Xiang He, Farzana Z Ali, Russell Rozensky, Christine DeLorenzo

Abstract read
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samir BathejaYale University, United States of America. Electronic address: Samir.Batheja@yale.edu.
Jie YangStony Brook University, United States of America.
Yunhan LiaoStony Brook University, United States of America.
Kenneth WenglerMount Sinai, United States of America.
Xiang HeNorthwell Health, United States of America.
Farzana Z AliUCLA, United States of America.
Russell RozenskyStony Brook University, United States of America.
Christine DeLorenzoStony Brook University, United States of America.

Funding

Advancing Personalized Antidepressant Treatment Using PET/MRIR01MH104512 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI DELORENZO, CHRISTINE · 2015 to 2018
$2.9M
NIMH NIH HHS R01 MH104512
6 · The paper itself

Abstract

In major depressive disorder (MDD), it is unclear whether fatigue is a result of poor sleep or depression, and its biological basis is unknown. To explore this, Magnetic Resonance Spectroscopy (

Indexed as

Fatiguegamma-Aminobutyric AcidGyrus CinguliMajor Depressive DisorderSleepAdultFemaleGlutamic AcidGlutamineHumansMagnetic Resonance SpectroscopyMaleSeverity of Illness IndexYoung Adultgamma-Aminobutyric AcidGlutamic AcidGlutamineDepressionFatigueGABAGlxMagnetic resonance spectroscopySleep

Identifiers

PMID41485508
PMCPMC13557011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.