Evidence map›Paper›PMID 41485466›Full record

ArticleCell stem cell2026

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration.

Nathalie Saurat, Andrew P Minotti, Maliha T Rahman, Trisha Sikder, Chao Zhang, Daniela Cornacchia, Johannes Jungverdorben, Gabriele Ciceri, Doron Betel, Lorenz Studer

Abstract readPublished Erratum
In one paragraph

Article in Cell stem cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nathalie Saurat
Andrew P Minotti
Maliha T Rahman
Trisha Sikder
Chao Zhang
Daniela Cornacchia
Johannes Jungverdorben
Gabriele Ciceri
Doron Betel
Lorenz Studer

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Novel strategies for induction of aging in human PSC-derived lineages for modeling Alzheimer's DiseaseR01AG054720 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI Doron Betel, LORENZ P. STUDER · 2017 to 2026
$4.5M
Programming age in iPS models of Alzheimer's diseaseR01AG056298 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI STUDER, LORENZ P. · 2017 to 2021
$2.2M
NCI NIH HHS P30 CA008748NIA NIH HHS R01 AG054720NIA NIH HHS R01 AG056298
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41485466
PMCPMC12973372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.