Evidence map›Paper›PMID 41485355›Full record

ArticlePsychiatry research. Neuroimaging2026

Altered hippocampal shape morphology in schizophrenia and at-risk mental state.

Yoichiro Takayanagi, Dominic Padova, Can Ceritoglu, Daiki Sasabayashi, Shimako Nishiyama, Haruko Kobayashi, Kazumi Sakamoto, Mizuho Takayanagi, Kyo Noguchi, Noa Tsujii and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yoichiro TakayanagiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Arisawabashi Hospital, Toyama, Japan. Electronic address: ytakayan1@outlook.jp.
Dominic PadovaCenter for Imaging Science and Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
Can CeritogluCenter for Imaging Science and Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
Daiki SasabayashiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Shimako NishiyamaDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Health Administration Center, University of Toyama, Toyama, Japan.
Haruko KobayashiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Kazumi SakamotoDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Mizuho TakayanagiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Arisawabashi Hospital, Toyama, Japan.
Kyo NoguchiDepartment of Radiology, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Noa TsujiiDepartment of Child Mental Health and Development, Toyama University Hospital, Toyama, Japan.
Michio SuzukiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
J Tilak RatnanatherCenter for Imaging Science and Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
Tsutomu TakahashiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
NIBIB NIH HHS P41 EB031771
6 · The paper itself

Abstract

backgroundStructural and functional alterations of the hippocampus have been reported to be associated with prodromal symptoms of psychotic disorders in individuals with an at-risk mental state (ARMS), as well as with the pathophysiology and symptomatology of psychotic conditions such as schizophrenia (SZ).

methodsIn this study, 3-tesla 3D MRI scans were obtained from 81 SZ patients, 56 individuals with ARMS, and 90 healthy controls. We evaluated hippocampal surface morphology using large deformation diffeomorphic metric mapping and conducted cluster-wise comparisons of the hippocampal surfaces across the groups.

resultsA common surface expansion in the right cornu ammonis (CA)3 was observed in SZ and ARMS groups compared to healthy subjects. In SZ patients, additional surface expansions were noted in the right CA1, hippocampal tail, and presubiculum. A higher dosage of antipsychotic medication was associated with surface compression in the bilateral hippocampal tail.

conclusionCommon hippocampal surface alterations may underlie vulnerability to psychosis. Further surface expansions may be associated with the manifestation of overt psychotic symptoms. Such surface changes may be affected by antipsychotic medications.

Indexed as

HippocampusSchizophreniaAdultFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleProdromal SymptomsPsychotic DisordersYoung AdultAt-risk mental stateHippocampusMRISchizophreniaShape analysis

Identifiers

PMID41485355
PMCPMC12934258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.