Evidence map›Paper›PMID 41485219›Full record

ArticleCell reports2026

Rapid plasticity of default-mode local network architectures following adult-onset blindness.

Lukas Mesik, Katie Hang Thanh Pham, Keqin Ding, Yiyang Martin Huang, Daniel Severin, Alfredo Kirkwood, Andrei Dragomir, Nitish Thakor, Hey-Kyoung Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lukas MesikZanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Katie Hang Thanh PhamZanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Keqin DingDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Yiyang Martin HuangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Daniel SeverinZanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Alfredo KirkwoodZanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Andrei DragomirThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore.
Nitish ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Hey-Kyoung LeeZanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: heykyounglee@jhu.edu.

Funding

Global Synpatic Plasticity Mechanisms in Visual CortexR01EY014882 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Hey-Kyoung Lee · 2004 to 2026
$7.9M
NEI NIH HHS R01 EY014882
6 · The paper itself

Abstract

Sensory cortices are not silent in the absence of sensory inputs but generate spontaneous activity intrinsic to the cortical circuit referred to as default-mode activity. Here, we report that spontaneous activity of excitatory and inhibitory neuronal types in layer 2/3 of the adult primary visual cortex (V1) exhibits quite stable default-mode local network architectures, which undergo rapid and selective restructuring following bilateral enucleation (EN), a model of adult-onset blindness. Spontaneous activity of both pyramidal (Pyr) and parvalbumin (PV) neurons rapidly and persistently increased following EN, but the default-mode network architecture of only Pyr rapidly rearranged and stabilized. Vasoactive intestinal peptide (VIP) neuronal network also restructured rapidly after EN, but their spontaneous activity increase was delayed. Somatostatin (SOM) neuronal network was quite stable. Our results indicate that adult-onset blindness rapidly and selectively modifies the stable default-mode local network architectures of V1, independent of increases in spontaneous activity, reflecting rapid adaptation to vision loss.

Indexed as

BlindnessNerve NetNeuronal PlasticityPrimary Visual CortexAdultAnimalsHumansMaleParvalbuminsPyramidal CellsSomatostatinVasoactive Intestinal PeptideVisual CortexParvalbuminsSomatostatinVasoactive Intestinal Peptideadult cortical plasticityCP: neurosciencecross-modal plasticitylocal network plasticitysensory plasticityspontaneous activityvisual cortex

Identifiers

PMID41485219
PMCPMC12934523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.