ReviewAntonie van Leeuwenhoek2026
A comprehensive review on "bushy bunched" filamentous fungal mycelial hyphae for next-generation surgical sutures - a sustainable approach.
Review in Antonie van Leeuwenhoek, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
2 authors.
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Abstract
Amidst the escalating demand for biocompatible, biodegradable, and ecologically responsible materials in clinical biomaterial science, filamentous fungal hyphae have emerged as a compelling and underexplored resource for the development of medical sutures. This review consolidates and critically evaluates the utilization of fungal mycelial networks, primarily from filamentous fungi within the Zygomycota phylum, as structural frameworks for biofunctional surgical sutures. The hyphal architecture, characterized by its hierarchical organization, tensile robustness, and inherent biodegradability, presents a biologically congruent alternative to traditional synthetic polymers and animal-derived fibers. Emphasis is placed on fabrication methodologies such as wet-spinning and bioextrusion, which enable the morphological refinement and mechanical tuning of fungal filaments into monofilament and multifilament suture constructs. Furthermore, this review delineates the biocompatibility profiles, degradation kinetics, and sterilization challenges associated with fungal-based materials, while addressing regulatory considerations and translational hurdles. Collectively, the synthesis of interdisciplinary insights highlights the potential of filamentous fungal hyphae as a paradigm-shifting innovation in surgical sutures and sustainable medical textiles.
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41485191What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.