Evidence map›Paper›PMID 41485169›Full record

ArticleApplied biochemistry and biotechnology2026

Protopine-Enriched Dactylicapnos Scandens Root Fraction Improves Glucose Homeostasis in Cell and Mouse Models Via AMPK/PEPCK/G6Pase Modulation.

Rupam Buragohain, Semim Akhtar Ahmed, Bhabajyoti Das, Pranamika Sarma, Pranjan Barman, Seydur Rahman, Naba Kumar Hazarika, Manas Das, N C Talukdar, Jagat Chandra Borah

Abstract read
PubMed Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rupam Buragohain *Department of Biotechnology, Gauhati University, Guwahati, Assam, 781014, India.
Semim Akhtar Ahmed *Chemical Biology Laboratory 1, Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Paschim Boragaon, Guwahati, Assam, 781035, India.
Bhabajyoti DasDepartment of Zoology, Gauhati University, Guwahati, Assam, 781014, India.
Pranamika SarmaChemical Biology Laboratory 1, Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Paschim Boragaon, Guwahati, Assam, 781035, India.
Pranjan BarmanDepartment of Biotechnology, Gauhati University, Guwahati, Assam, 781014, India. pranjan.barman@gauhati.ac.in.
Seydur RahmanChemical Biology Laboratory 1, Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Paschim Boragaon, Guwahati, Assam, 781035, India.
Naba Kumar HazarikaDepartment of Rasasastra and Bhaishjya Kalpana, Govt. Ayurvedic college, Guwahati, Assam, 781014, India. nabasuper11@gmail.com.
Manas DasDepartment of Zoology, Gauhati University, Guwahati, Assam, 781014, India.
N C TalukdarChemical Biology Laboratory 1, Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Paschim Boragaon, Guwahati, Assam, 781035, India.
Jagat Chandra BorahChemical Biology Laboratory 1, Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Paschim Boragaon, Guwahati, Assam, 781035, India. borahjc@gmail.com.ORCID http://orcid.org/0000-0001-6876-2659

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR25194/NER/95/1071/2017dated 15/3/2019
6 · The paper itself

Abstract

Dactylicapnos scandens (D. Don) Hutch is popular among traditional healthcare providers in Nagaland, North-East India and Bai communities in China. Current investigation analyses traditional claims of Dactylicapnos scandens root tuber extract to control diabetes through down-regulation of hepatic gluconeogenesis and oxidative stress in diabetes mellitus (Type 2) in both in vitro (cell culture) and in vivo (animal model) systems. Potential of Dactylicapnos scandens against diabetes was demonstrated in free fatty acid (FFA)-induced CC1 liver cells and streptozotocin-induced diabetic male Swiss albino mice. Enriched bioactive fraction was prepared through activity guided fractionation and major component was identified to be protopine. Enriched fraction of Dactylicapnos scandens root tuber and its isolated compound, protopine increased glucose uptake by the liver cells in FFA-induced condition. Further, the enriched fraction down regulated gluconeogenesis enzymes (Glucose-6-phosphatase and phosphoenolpyruvate kinase) through AMP-activated protein kinase (AMPK) modulation in both CC1 liver cells and liver tissues of diabetic mice. Moreover, in vivo experiment with enriched fraction containing protopine enhanced the tolerance of glucose as well as insulin level in plasma. Antidiabetic activity of enriched fraction containing protopine as a major component was also supported by histopathological analysis. Overall, protopine containing root tuber enriched fraction of Dactylicapnos scandens regulates antihyperglycemic efficacy in CC1 liver cells and in Swiss albino mice induced with diabetes via ameliorating AMPK/PEPCK/G6Pase signalling pathway.

Indexed as

AMP-Activated Protein KinasesDiabetes Mellitus, ExperimentalGlucoseGlucose-6-PhosphataseHomeostasisOrchidaceaePlant ExtractsPlant RootsAnimalsCell LineGluconeogenesisMaleMiceAMP-Activated Protein KinasesGlucoseGlucose-6-PhosphatasePlant ExtractsDactylicapnos scandensEthnomedicinal plantHepatic gluconeogenesisType 2 diabetes mellitus

Identifiers

PMID41485169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.