Evidence map›Paper›PMID 41485128›Full record

ArticleAutophagy2026

TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons.

Daniel A Mordes, Julie Smeyers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel A MordesInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences and Department of Pathology, University of California, San Francisco, CA, USA.
Julie SmeyersInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences and Department of Pathology, University of California, San Francisco, CA, USA.

Funding

Defining TBK1-associated autophagy networks in neuronsR01AG089849 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel Adam Mordes · 2024 to 2026
$2.3M
NIA NIH HHS R01 AG089849
6 · The paper itself

Abstract

Haploinsufficiency of TBK1 causes familial ALS and frontotemporal dementia (FTD), yet the mechanisms by which TBK1 loss leads to neurodegeneration remain unclear. Using deep proteomics and phospho-proteomics, we demonstrate that TBK1 regulates select macroautophagy/autophagy factors, targeting cargo receptors and autophagy initiation factors, and also sustains the phosphorylation of the late endosomal marker RAB7A in stem cells and stem cell-derived excitatory neurons. We further uncovered novel TBK1-dependent phosphorylation sites in the key autophagy protein SQSTM1/p62. Loss of TBK1 function results in a cell-autonomous neurodegenerative phenotype characterized by impaired neurite outgrowth and lysosomal dysfunction.

Indexed as

AutophagyEndosomesLysosomesNeuronsProtein Serine-Threonine KinasesHumansPhosphorylationrab7 GTP-Binding Proteinsrab GTP-Binding ProteinsSequestosome-1 ProteinSignal TransductionProtein Serine-Threonine Kinasesrab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanrab GTP-Binding ProteinsSequestosome-1 ProteinSQSTM1 protein, humanTBK1 protein, humanlysosomesneurodegenerationproteomicsselective autophagyTBK1

Identifiers

PMID41485128
PMCPMC12931900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.