Evidence map›Paper›PMID 41485070›Full record

ArticleJournal of neuroinflammation2026

Microbiota-derived IPA mitigates post-stroke neuroinflammation by inhibiting TREM2-dependent pyroptosis.

Jun-Min Chen, Cong Zhang, Lu-Lu Yu, Jian-Xu Sun, Jiang-Hao Zhang, Lu Chen, Fei Zhu, Guang Shi, Lan Yang, An-Chen Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jun-Min ChenDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Cong ZhangDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lu-Lu YuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Jian-Xu SunKey Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.
Jiang-Hao ZhangDepartment of Anesthesiology, Clinical College of Hebei Medical University, Shijiazhuang, China.
Lu ChenDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Fei ZhuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Guang ShiDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lan YangDepartment of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
An-Chen GuoChina National Clinical Research Center for Neurological Diseases, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Jian-Ping WuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China. biojpwu@ccmu.edu.cn.
Tie-Shan TangKey Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. tangtsh@ioz.ac.cn.
Qun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China. wangq@ccmu.edu.cn.

Funding

Capital Health Research and Development of Special grants 2024-1-2041Faculty Development grants from Hubei University of Medicine K1297701, J.WHebei Province Medical Science Research Project 20221060National Key Research and Development Program of China 2022YFC2503800National Key Research and Development Program of China 2023YFA1801904 and 2025YFA1805102National Natural Science Foundation of China 82501758National Natural Science Foundation of China U24A20695 and 82371449Natural Science Foundation of Beijing Municipality 7232045 and Z200024the Introduction of Foreign Intelligence Program of Hebei Province 13000023P002DB4102678
6 · The paper itself

Abstract

Ischemic stroke remains the leading cause of long-term disability globally, underscoring the urgent need for novel therapeutic strategies. Here, we explore a microbiota-gut-brain axis that provides valuable insights for achieving this objective. Utilizing a distal middle cerebral artery occlusion (dMCAO) mouse model, we observed a marked reduction in Duncaniella muris (D. muris) post-stroke, alongside dysregulated tryptophan metabolism, characterized by elevated levels of indole-3-lactic acid (ILA) and decreased indole-3-propionic acid (IPA). D. muris supplementation restored metabolic balance by converting ILA to IPA, leading to significant improvements in neurological recovery. Mechanistically, IPA exerted neuroprotective effects by attenuating neuroinflammation through TREM2-dependent modulation of microglial activation, promoting an anti-inflammatory phenotype and inhibiting NLRP3 inflammasome-mediated pyroptosis. These findings highlight the therapeutic potential of the D. muris-IPA-TREM2-pyroptosis axis as a novel target for ischemic stroke treatment, providing a basis for future microbiome-based interventions aimed at improving stroke outcomes.

Indexed as

Gastrointestinal MicrobiomeIndolesMembrane GlycoproteinsNeuroinflammatory DiseasesPyroptosisReceptors, ImmunologicStrokeAnimalsMaleMiceMice, Inbred C57BLIndolesMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseDuncaniella murisGut microbiotaIndole-3-propionic acidIschemic strokePyroptosisTREM2

Identifiers

PMID41485070
PMCPMC12866579

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.