Evidence map›Paper›PMID 41485053›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

CTRP1 regulates skeletal muscle differentiation through quality control of mitochondrial dynamics and function.

Sora Han, Youjeong Jang, Hyun Jeong Joo, Hye In Ka, Se Hwan Mun, Hai-Anh Nguyen, Doyeon Park, Yoohyun Jung, Doyeong Ko, Bo Ram Sohn and 6 more

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Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sora HanResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea.
Youjeong JangDepartment of Biological Sciences, Sookmyung Women's University, Seoul, Korea.
Hyun Jeong JooDepartment of Biological Sciences, Sookmyung Women's University, Seoul, Korea.
Hye In KaResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea.
Se Hwan MunResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea.
Hai-Anh NguyenResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea.
Doyeon ParkDepartment of Biological Sciences, Sookmyung Women's University, Seoul, Korea.
Yoohyun JungDepartment of Biological Sciences, Sookmyung Women's University, Seoul, Korea.
Doyeong KoResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea.
Bo Ram SohnResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea.
Seong Keun SonnDepartment of Life Sciences, Ewha Womans University, Seoul, Korea.
Goo Taeg OhDepartment of Life Sciences, Ewha Womans University, Seoul, Korea.
Young-Chul ChoiDepartment of Neurology, Gangnam Severance, College of Medicine, Yonsei University, Seoul, Korea.
So-Young ParkDepartment of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.
Sung-Eun KimDepartment of Food and Nutrition, Sookmyung Women's University, Seoul, Korea.
Young YangResearch Institute of Women's Health, Sookmyung Women's University, Seoul, Korea; Department of Biological Sciences, Sookmyung Women's University, Seoul, Korea. Electronic address: yyang@sookmyung.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction is a hallmark of myopathies and impaired skeletal muscle differentiation. Here, we demonstrate that C1q/TNF-related protein 1 (CTRP1) is essential for maintaining mitochondrial dynamics and supporting myogenic differentiation. Loss of CTRP1 in myoblasts and in skeletal muscle-specific-knockout (CTRP1 KO

Indexed as

AdipokinesCell DifferentiationMitochondriaMitochondrial DynamicsMuscle DevelopmentMuscle, SkeletalAnimalsDynaminsHumansMiceMice, KnockoutMitochondria, MuscleMuscle Fibers, SkeletalMyoblastsAdipokinesCTRP1 protein, mouseDnm1l protein, mouseDynaminsadenovirus-mediated gene deliveryC2C12differentiationfissionknockout mousemitochondriamitochondria transplantationmuscle dystrophymyogenesisprimary myoblasts

Identifiers

PMID41485053
PMCPMC13069333

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.