Evidence map›Paper›PMID 41484999›Full record

ArticleVeterinary research2026

The whole genome sequencing offers insights into the susceptibility to the foot-and-mouth disease virus carrier state.

Zhihui Zhang, Zhidong Teng, Shuanghui Yin, Suyu Mu, Sumin Wei, Yaozhong Ding, Yun Zhang, Shuang Wang, Yijing Li, Shiqi Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhihui ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Zhidong TengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Shuanghui YinState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Suyu MuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Sumin WeiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Yaozhong DingState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Yun ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Shuang WangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Yijing LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Shiqi SunState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Huichen GuoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China. guohuichen@caas.cn.

Funding

Key R&D Program of Ningxia province 2024BBF02017National Key R&D Program of China 2021YFD1800303Technology innovation guidance program of Gansu Province 24CXNA030thereby acting 32301127
6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) establishes persistent infection in more than 50% of infected ruminants, irrespective of vaccination status, implicating potential contributions of host genetic variations to viral persistence. In this study, we conducted whole-genome resequencing of a cohort of 22 cattle, comprising 7 carriers and 15 noncarriers. Clean reads were mapped to the cattle (Bos taurus) reference genome (ARS-USD1.2) and cattle-yak (Bos taurus × Bos grunniens) haplotype assemblies. We identified 24 shared carrier-specific variants across genomes and 31 carrier-specific variants restricted to the cattle-yak haplotypes. These carrier‑specific variants were primarily located in genes involved in olfactory perception, cell development and morphological maintenance, transcriptional and translational regulation, signal transduction, metabolic homeostasis, stress resistance, and immune cell regulation. The combined functional impact of these variants may influence innate immune regulatory capacity and shape the magnitude of adaptive immune activation, thereby conferring distinct antiviral capacities and facilitating viral persistence. Our findings offer a comprehensive catalog of candidate genetic variants potentially associated with persistent FMDV infection, providing novel insights into the genetic architecture underlying host's susceptibility to viral persistence.

Indexed as

Carrier StateCattle DiseasesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusGenetic Predisposition to DiseaseAnimalsCattleWhole Genome Sequencingdisease susceptibilityFoot-and-mouth disease virusgenetic variationsSNPsviral persistence

Identifiers

PMID41484999
PMCPMC12866560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.