ArticleJournal of biological engineering2026
Thiol release improvement in Saccharomyces cerevisiae oenological strains by CRISPR/Cas9-based IRC7 molecular cisgenesis.
Article in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Uncorking wine yeast genomics from grape to glass.FEMS yeast research · 2026Review
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4 authors.
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Abstract
backgroundPolyfunctional thiols are essential contributors to the aromatic profile of varietal white wines like Sauvignon Blanc. These compounds are released during fermentation by Saccharomyces cerevisiae cells from grape-derived precursors, with the carbon-sulfur β-lyase encoded by the IRC7 gene playing a crucial role. However, most oenological yeast strains lack the fully functional IRC7 allele, limiting their thiol-releasing ability.
resultsIn this study, we used CRISPR/Cas9-based cisgenesis to replace the native allele with the fully active IRC7
conclusionsThis work demonstrates that targeted IRC7 gene editing via CRISPR/Cas9 is a precise and efficient strategy to enhance thiol production in oenological yeasts, without compromising fermentative behavior or aromatic identity. Importantly, although the strains are formally GMOs, the modification mimics natural allelic variation. Our findings provide a foundation for developing next-generation wine yeasts optimized for high-aroma varietal wines and support the broader application of genome editing in fermentation biotechnology.
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