ArticleTrials2026
Physiologic effects of two non-invasive respiratory support therapies (continuous positive airway pressure versus high-flow nasal oxygenation) in patients with acute respiratory distress syndrome: study protocol for a randomized clinical trial.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06694311 (Physiologic Effects of Two Non-invasive Respiratory Support Therapies), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiologic Effects of Two Non-invasive Respiratory Support Therapies (continuous Positive Airway Pressure Vs High Flow Nasal Oxygenation) in Patients with Acute Respiratory Distress Syndrome: a Randomized Clinical Trial.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory distress syndrome (ARDS) is the acute hypoxemic respiratory failure that presents with non-cardiogenic pulmonary opacities. Patients receiving non-invasive respiratory support might present with high transpulmonary pressure, pulmonary strain, and pendelluft, which contribute to the development of patient self-inflicted lung injury (P-SILI). Experimental studies have identified that continuous positive airway pressure (CPAP) is successful in attenuating P-SILI effectors compared to high-flow nasal oxygenation (HFNO). However, it remains uncertain whether this attenuation is associated with a reduction in lung injury and improved clinical outcomes.
methodsThis is a multicenter, randomized, open-label, controlled trial. One hundred and twenty non-intubated patients with established ARDS will be randomly assigned to receive non-invasive respiratory support with either CPAP 12 cmH DISCUSSION: This study will assess the potential role of CPAP in attenuating P-SILI effectors and inflicting less biological lung injury compared to HFNO. This physiologic effect may lead to lower rates of tracheal intubation and mortality. This project will provide new knowledge on the respiratory management of non-intubated ARDS patients, a subject where evidence is lacking.
trial registrationClinicalTrials.gov NCT06694311. Registered on 18 November 2024 as HCB/2023/1105.
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