ArticlePerioperative medicine (London, England)2026
Early plasma syndecan-1 dynamics and their prognostic value in major thoracic and abdominal surgery: a prospective observational study.
Article in Perioperative medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
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Abstract
backgroundGlycocalyx degradation, reflected by syndecan-1 shedding, is implicated in microcirculatory dysfunction and inflammatory responses. The present study aimed to assess early postoperative changes in plasma syndecan-1 levels following major thoracic and abdominal surgery, and their association with 30-days postoperative complications.
methodsA prospective, single-center observational cohort study included 107 patients. Syndecan-1 levels were measured preoperatively and two and 18 h after surgery. Associations with clinical and intraoperative variables were evaluated using univariate linear regression. The predictive performance of syndecan-1 for major complications and mortality within 30 days was assessed via receiver operating characteristic (ROC) analysis.
resultsThe median syndecan-1 values after two hours of surgery were 958 pg/mL (IQR 654–2665). No significant associations were found with comorbidities, surgical approach, intraoperative factors, or complications (all p > 0.05). Syndecan-1 showed poor predictive performance for major complications and mortality within 30 days (AUC 0.52; 95% CI: 0.40–0.63; p = 0.765).
conclusionSyndecan-1 levels vary widely postoperatively and are not associated with key perioperative variables or outcomes. These findings suggest limited utility of syndecan-1 as a biomarker for perioperative risk stratification in this setting.
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