Evidence map›Paper›PMID 41484871›Full record

ArticleCancer cell international2026

VMP1 inhibits the progression of breast cancer via regulating PI3K/AKT and MEK/ERK signaling pathway.

Shuzhao Chen, Yuanke Liang, Huan Chen, Chengyu Wu, Zhenhao Wang, Ruiqian Yang, Xinqiang Fang, Yanyang Ma, Haoyu Lin, Xiaolong Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuzhao Chen *Department of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Yuanke Liang *Department of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Huan Chen *Shenshan Medical Centre, Memorial Hospital of Sun Yat-sen University, Shanwei, 516600, China.
Chengyu WuDepartment of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Zhenhao WangDepartment of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Ruiqian YangDepartment of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Xinqiang FangDepartment of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Yanyang MaDepartment of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China.
Haoyu LinDepartment of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou, 515000, China. rainlhy@stu.edu.cn.
Xiaolong WeiDepartment of Pathology, Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515000, China. weixiaolonghh@126.com.

Funding

GuangDong Basic and Applied Basic Research Foundation 2023A1515220204Natural Science Foundation of Guangdong Province 2023A1515010252Natural Science Foundation of Guangdong Province 2024A1515030294Natural Science Foundation of Guangdong Province 2025A1515012618Postdoctoral Fellowship Program of CPSF GZC20231518
6 · The paper itself

Abstract

backgroundVacuolar membrane protein 1 (VMP1) is an endoplasmic reticulum - resident and multi - spanning membrane protein involved in various human cancers. However, its biological functions and molecular mechanisms in breast cancer remain underexplored.

methodsGene expression profiling was used to determine VMP1 levels. Western blot, qRT - PCR, and single - cell analysis were employed to confirm the findings. Functional assays such as knockdown and overexpression experiments were carried out to assess the effects on cell proliferation, colony formation, and migration. In vivo tumor growth experiments were also conducted. Additionally, clinical analysis of 117 breast cancer patient samples was performed to study the correlation between VMP1 expression and molecular subtypes.

resultsVMP1 was significantly upregulated in MCF − 7 cells line. Knockdown of VMP1 enhanced cell proliferation, colony formation, and migration, while overexpression suppressed tumor cell malignancy and inhibited tumor growth in vivo. Mechanistically, VMP1 was found to regulate key oncogenic signaling pathways, including PI3K/AKT and MEK/ERK. Clinical analysis showed that VMP1 expression was correlated with molecular subtypes.

conclusionsIn conclusion, our findings suggest that VMP1 plays a crucial role in breast cancer progression, and modulation of its expression or activity may offer a therapeutic strategy.

Indexed as

Breast cancerPI3K/AKT and MEK/ERK pathwaysTumor progressionVacuole membrane protein 1

Identifiers

PMID41484871
PMCPMC12866031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.