ArticleBiotechnology for biofuels and bioproducts2026
Enhanced extracellular respiration of engineered Bacillus subtilis via anodic electro-fermentation with pH optimisation.
Article in Biotechnology for biofuels and bioproducts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Leveraging alternative electron acceptors to support anaerobic metabolism in industrially relevant microorganisms holds substantial biotechnological potential, especially when coupled to anodic electro-fermentation, which provides a non-depleting electron sink to the microorganisms. Bacillus subtilis is a widely used industrial workhorse for biochemical production, valued for its genetic tractability and environmental stress tolerance. However, the anaerobic, anodic metabolism of B. subtilis has been constrained by limited redox flexibility. Here, deletion of ldh (lactate dehydrogenase) to restrict fermentative NAD⁺ regeneration enabled engineered B. subtilis to survive anaerobically via anodic respiration, partially oxidising glucose while steering the metabolism toward 2,3-butanediol. The anodic metabolism showed enhanced extracellular electron transfer mediated by ferricyanide, with the highest current density of 0.77 mA/cm
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