ArticleReproductive biology and endocrinology : RB&E2026
The type of endometrial preparation for embryo transfer after egg donation affects obstetric outcomes and the expression of placental angiogenic biomarkers.
Article in Reproductive biology and endocrinology : RB&E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the impact of natural cycle/modified natural cycle and artificial cycle in oocyte donation pregnancies on obstetric/neonatal outcomes and placental angiogenic biomarkers.
methodsA total number of 201 singleton live births resulted from in vitro fertilization with oocyte donation were enrolled: n = 70 after natural cycle/modified natural cycle endometrial preparation and n = 131 after artificial cycle endometrial preparation. Moreover, 35 placental biopsies were collected: n = 12 after natural cycle/modified natural cycle endometrial preparation, n = 23 after artificial cycle endometrial preparation. Finally, 24 placentae from women with a spontaneous, healthy singleton pregnancy at term, who showed no signs of maternal, placental or fetal disease were used as control.
resultsWe reported a lower incidence of both hypertensive disorders of pregnancy (7.1% Vs 18.3%, p < 0.05), including preeclampsia, and placental previa (0 Vs 6.1%, p < 0.05) in natural/modified natural cycles compared to artificial cycle. Furthermore, better neonatal outcomes, at least in terms of low birth weight (5.7% Vs 20.9%, p < 0.05) and intensive care unit admission (2.9% Vs 15.6%, p < 0.05), were observed. From a molecular point of view, a significant gene over-expression of pro-angiogenic placental growth factor and vascular endothelial growth factor were obtained in natural cycles. Conversely, anti-angiogenic Soluble Fms-Like Tyrosine Kinase- 1 levels were increased in artificial cycle group placentae compared to natural/modified natural cycle and controls.
conclusionsNatural/modified cycles should be promoted as preferential approach for endometrial preparation in oocyte donation pregnancies, at least when regular (or inducible) ovulatory cycles are present.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.