Evidence map›Paper›PMID 41484757›Full record

ArticleCEN case reports2026

IgG-type lymphoplasmacytic lymphoma with light chain deposition disease.

Toshikazu Ozeki, Shun Ito, Takuya Sugiura, Yuki Yokoe, Kaoru Yasuda

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Toshikazu OzekiDepartment of Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Michishita 3-35, Nakamura-Ku, Nagoyai, Aich, 453-8511, Japan. ozeki.nep@chubuh.johas.go.jp.ORCID 0000-0003-1541-0865
Shun ItoDepartment of Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Michishita 3-35, Nakamura-Ku, Nagoyai, Aich, 453-8511, Japan.
Takuya SugiuraDepartment of Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Michishita 3-35, Nakamura-Ku, Nagoyai, Aich, 453-8511, Japan.
Yuki YokoeDepartment of Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Michishita 3-35, Nakamura-Ku, Nagoyai, Aich, 453-8511, Japan.
Kaoru YasudaDepartment of Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Michishita 3-35, Nakamura-Ku, Nagoyai, Aich, 453-8511, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphoplasmacytic lymphoma (LPL) is a rare, indolent B-cell malignancy, with the IgG subtype being particularly uncommon. We present a case of IgG-type LPL complicated by kidney dysfunction due to light chain deposition disease (LCDD), representing the first documented instance of LCDD-related kidney impairment in this lymphoma subtype. A 65-year-old man presented with lower extremity edema and was found to have significant kidney dysfunction. Laboratory tests revealed elevated serum creatinine, heavy proteinuria, and a markedly skewed free light chain κ/λ ratio. Immunofixation electrophoresis identified an IgG-κ monoclonal protein and Bence Jones protein (κ light chain). Bone marrow biopsy confirmed LPL with a MYD88 L265P mutation, while kidney biopsy demonstrated mesangial proliferation, interstitial fibrosis, and granular κ light chain deposits consistent with LCDD. Given the rarity of IgG-type LPL with kidney involvement, this case underscores the importance of a thorough diagnostic workup in patients presenting with both hematologic malignancy and kidney dysfunction. Early recognition and appropriate management are critical for improving patient outcomes. As non-IgM LPL cases have historically been associated with poorer prognoses compared to Waldenström macroglobulinemia, the identification of underlying kidney complications such as LCDD is essential. Further accumulation of similar cases is needed to establish optimal treatment strategies.

Indexed as

Immunoglobulin GImmunoglobulin Light ChainsWaldenstrom MacroglobulinemiaAgedBence Jones ProteinBiopsyBone MarrowHumansImmunoglobulin kappa-ChainsKidneyMaleMyeloid Differentiation Factor 88Bence Jones ProteinImmunoglobulin GImmunoglobulin kappa-ChainsImmunoglobulin Light ChainsMYD88 protein, humanMyeloid Differentiation Factor 88Light chain deposition diseaseLymphoplasmacytic lymphoma

Identifiers

PMID41484757
PMCPMC12764716

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