ArticleIrish journal of medical science2026
Clinical characteristics, management and outcomes of hyperemesis gravidarum: a retrospective study in an Irish maternity hospital.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHyperemesis Gravidarum (HG) in pregnancy is a severe form of nausea and vomiting resulting in dehydration, weight loss and declining mental health. Research on the clinical characteristics and management of HG in Ireland is limited.
aimTo describe a cohort of women with HG attending an Irish Maternity Hospital.
methodsA retrospective chart review of 198 women referred for HG management in an urban stand-alone maternity hospital in Dublin between 2020-2023. Data included medical and obstetric history, management, symptoms and birth outcomes.
resultsMost (64.8%) were multiparous, with 77% reporting previous HG. The majority (76.3%) presented in the first trimester. PUQE scores indicated mild (3.4%), moderate (48.3%), or severe (48.3%) nausea and vomiting, and 72.1% rated their wellbeing 5 or lower (on a scale of 0-10). Mean weight loss from pre-pregnancy to first presentation was-2.64kg (SD 3.9), with 39% losing >5%. Dehydration (61.3%) and ketonuria (42.8%) were common. Mean duration of HG care was 11.04 (SD 8.4) weeks. Nearly half (49.5%) trialled 3-4 medications, with 87.9% prescribed Doxylamine/Pyridoxine and/or Prochlorperazine. Hospital resource use was high; 76% required day ward management, 78% attended A&E, and 36.9% needed overnight admission, at least once. Among 187 live births, 55.2% were male, 70% were vaginal deliveries, 9.1% were small for gestational age (<10
conclusionHG significantly impacts maternal health and places demands on hospital resources. While birthweight centiles were generally normal, HG's potential long-term effects on child health warrant further investigation.
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