Evidence map›Paper›PMID 41484734›Full record

ArticleApplied biochemistry and biotechnology2026

ALKBH5 Accelerates the Progression of Head and Neck Squamous Cell Carcinoma by Decreasing Methylation of the lncRNA NEAT1.

Shu Zhang, Yunfei Bai, Boqian Wang, Haitao Ju

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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Shu Zhang *Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010110, China.
Yunfei Bai *Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010110, China.
Boqian WangDepartment of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010110, China.
Haitao JuDepartment of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, No.1, North Tongdao Road, Hohhot, 0HPSCC10110, Inner Mongolia, China. juhaitao305@163.com.ORCID http://orcid.org/0009-0007-5613-2087

Funding

Hohhot Religion High-quality Developmental and Advantageous Key Clinical Project of Neurological System Disease 2023NYFY LHYB007Inner Mongolia Autonomous Region Clinical Medicine Research Center of Nervous System Diseases Inner Mongolia Autonomous Region Clinical Medicine Research Center of Nervous System DiseasesInner Mongolia Medical University Affiliated Hospital Inner Mongolia Medical University Affiliated Hospital
6 · The paper itself

Abstract

Although N6-methyladenosine (m6A) demethylase alkylation repair homolog protein 5 (ALKBH5) is closely associated with the aggressiveness of head and neck squamous cell carcinoma (HNSCC), the underlying molecular mechanisms remain to be fully elucidated. In this study, we screened out a novel ALKBH5/lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1)/miR-654-3p/HOXA10 axis that participated in the regulation of HNSCC development. Specifically, lncRNA NEAT1 was found to be highly expressed in HNSCC tissues and cells, and deletion of NEAT1 suppressed cell proliferation and tumorigenesis, and promoted apoptosis and autophagy to hamper cancer progression in HNSCC. Mechanistic experiments verified that the stability and expressions of NEAT1 were positively regulated by ALKBH5-mediated m6A demethylation, and ALKBH5 deletion induced a suppressive effect on HNSCC cell malignancies were all abrogated by overexpressing NEAT1. In addition, we evidenced that NEAT1 promoted Homeobox A10 (HOXA10) expression via sponging miR-654-3p in a competing endogenous RNA (ceRNA)-dependent manner, and both miR-654-3p inhibition and HOXA10 overexpression recovered cancer malignancies in the NEAT1-deficient HNSCC cells. Taken together, we concluded that ALKBH5-induced m6A demethylation increased the stability and expression levels of NEAT1, and elevated NEAT1 facilitated cancer progression in HNSCC through regulating the downstream miR-654-3p/HOXA10 axis. This study provided potential biomarkers for the diagnosis, treatment and prognosis of HNSCC in clinic.

Indexed as

AlkB Homolog 5, RNA DemethylaseDisease ProgressionHead and Neck NeoplasmsRNA, Long NoncodingSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansMethylationMicroRNAsALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseHomeodomain ProteinsMicroRNAsNEAT1 long non-coding RNA, humanRNA, Long NoncodingAlkylation repair homolog protein 5Head and neck squamous cell carcinomaN6-methyladenosineNuclear paraspeckle assembly transcript 1

Identifiers

PMID41484734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.