Evidence map›Paper›PMID 41484732›Full record

ArticleApplied biochemistry and biotechnology2026

Hybrid Herbal-Synthetic Sunscreen Formulations: Boosting SPF With Hippophae Rhamnoides and Sapindus Mukorossi Extracts.

Pasupathi Murugesan, Kumar Thangarathinam, Natarajan Balasubramanian

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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Pasupathi MurugesanDepartment of Chemistry, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamilnadu, India.
Kumar ThangarathinamCavinkare Private limited, Chennai, 600032, Tamilnadu, India.
Natarajan BalasubramanianDepartment of Chemistry, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamilnadu, India. natarajb@srmist.edu.in.ORCID http://orcid.org/0000-0002-1401-1427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultraviolet (UV) radiation accelerates skin aging and carcinogenesis, driving the demand for safer sunscreens. This study evaluated the SPF-enhancing potential of Hippophae rhamnoides (Elaeagnaceae) and Sapindus mukorossi (Sapindaceae) extracts in octocrylene-based oil-in-water emulsions. Formulations with 5% octocrylene ± 5% herbal extracts were assessed for in vitro SPF, antioxidant activity, and stability. The Hippophae rhamnoides and octocrylene combination achieved the highest SPF (15.42 ± 0.60), a 2.4-fold increase over octocrylene alone (6.47 ± 0.74), while Sapindus mukorossi yielded 9.03 ± 0.65. Antioxidant assays showed superior radical scavenging for Hippophae rhamnoides formulations (IC₅₀: 18.4 µg/mL) compared with Sapindus mukorossi (29.6 µg/mL). All formulations remained physically and chemically stable over 8 weeks. These results demonstrate that Hippophae rhamnoides can markedly enhance photoprotection and reduce synthetic filter load, supporting the development of hybrid herbal-synthetic sunscreens. In vivo validation and photostability testing are recommended.

Indexed as

HippophaePlant ExtractsSapindaceaeSun Protection FactorSunscreening AgentsAcrylatesAntioxidantsEmulsionsHumansUltraviolet RaysAcrylatesAntioxidantsEmulsionsoctocrylenePlant ExtractsSunscreening AgentsHippophae rhamnoidesNatural UV filterOctocryleneSapindus mukorossiSun protection factorSunscreen

Identifiers

PMID41484732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.